Document Detail


Longitudinal Doppler measurements of spiral artery blood flow in relation to uterine artery blood flow.
MedLine Citation:
PMID:  19933474     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of this study was to examine the longitudinal relationship between Doppler flow velocity waveforms of the spiral artery (SA) and uterine artery (UA) in pregnant women. METHODS: Ninety-seven primigravidas with uncomplicated singleton pregnancies were analyzed. Spiral artery and combined UA velocity waveforms were assessed by transabdominal color Doppler sonography at gestational ages of 11 through 13, 14 through 17, and 18 through 24 weeks; each measurement was performed twice. The pulsatility index (PI) was calculated for the left and right UA, and the results were averaged as a combined UA. In addition, the presence of UA bilateral notching was reported. Bland-Altman plots and generalized estimating equations were used to assess intraobserver variability and the longitudinal relationship between SA and UA blood velocities. RESULTS: A total of 284 UA and 263 SA Doppler flow measurements were analyzed. Intraobserver variability rates for the SA and UA were 0.54 and 0.90, respectively. Results showed a continuous decrease of the mean PI in the SA and UA with increasing gestational age. Uterine artery bilateral notching was reported in 35%, 9%, and 3% of the cases at gestational ages of 11 through 13, 14 through 17, and 18 through 24 weeks. Generalized estimating equation analysis showed a significant correlation (r = 0.41) between the SA and UA (P < .0001). CONCLUSIONS: Uterine artery Doppler measurements in early pregnancy seem to accurately reflect peripheral resistance of SAs. Furthermore, trophoblastic invasion seems a continuous process in the first half of pregnancy, in which early UA bilateral notching is a physiologic event.
Authors:
Koen L Deurloo; Antoinette C Bolte; Jos W R Twisk; John M G van Vugt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine     Volume:  28     ISSN:  1550-9613     ISO Abbreviation:  J Ultrasound Med     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211547     Medline TA:  J Ultrasound Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1623-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, VU University Medical Center, PO Box 7017, 1007 MB Amsterdam, the Netherlands. kl.deurloo@vumc.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Flow Velocity / physiology*
Female
Humans
Image Interpretation, Computer-Assisted / methods*
Ultrasonography, Prenatal / methods*
Uterine Artery / physiology*,  ultrasonography*
Vascular Resistance / physiology
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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