Document Detail


Longitudinal Changes in Late Systolic Cardiac Load and Serum NT-proBNP Levels in Healthy Middle-Aged Japanese Men.
MedLine Citation:
PMID:  25194157     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: We determined whether any significant association exists between change in late systolic cardiac load with time, estimated by radial pressure waveform analysis, and development of cardiac hemodynamic stress in individuals with preserved cardiac function.
METHODS: Brachial-ankle pulse wave velocity, radial augmentation index (rAI), first peak of the radial pressure waveform (SP1), systolic and pulse pressure at the second peak of the radial pressure waveform (SP2 and PP2), and serum levels of N-terminal fragment B-type natriuretic peptide (NT-proBNP) were measured at the start (first examination) and at the end (second examination) of this 3-year study in healthy Japanese men (n = 1,851).
RESULTS: A stepwise multivariate linear regression analysis demonstrated that among the parameters of radial pressure waveform analysis and markers of arterial stiffness analyzed, only PP2 was significantly associated with serum NT-proBNP levels in study participants at both the first and second examinations. Furthermore, among the parameters analyzed, only change in PP2 was significantly correlated with the change in serum NT-proBNP levels during the study period (beta = 0.131, P < 0.001).
CONCLUSIONS: Sustained late systolic cardiac load might be a more significant determinant of the development of cardiac hemodynamic stress than sustained early systolic cardiac load or arterial stiffening in individuals with preserved cardiac function.
Authors:
Hirofumi Tomiyama; Toshio Nishikimi; Chisa Matsumoto; Kazutaka Kimura; Mari Odaira; Kazuki Shiina; Akira Yamashina
Related Documents :
22103447 - Cardiovascular actions of leptin in the subfornical organ are abolished by diet induced...
8378557 - Self-disclosure and coping styles in men with cardiovascular reactivity.
1560427 - Affective moderators of the cardiovascular response to stress in offspring of hypertens...
18997987 - Characterisation of left ventricular function by tissue doppler imaging technique in ne...
2970777 - Administration of enoximone in cardiogenic shock.
11038407 - Cardiovascular effects of 8 h of isocapnic hypoxia with and without beta-blockade in hu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-5
Journal Detail:
Title:  American journal of hypertension     Volume:  -     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© American Journal of Hypertension, Ltd 2014. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of a Brachial Cuff and Suprasystolic Waveform Algorithm Method to Noninvasively Derive Ce...
Next Document:  Diets Higher in Protein Predict Lower High Blood Pressure Risk in Framingham Offspring Study Adults.