Document Detail


Longitudinal assessment of hemodynamic endpoints in predicting arteriovenous fistula maturation.
MedLine Citation:
PMID:  22892020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arteriovenous fistula (AVF) nonmaturation is currently a significant clinical problem; however, the mechanisms responsible for this have remained unanswered. Previous work by our group and others has suggested that anatomical configuration and the corresponding hemodynamic endpoints could have an important role in AVF remodeling. Thus, our goal was to assess the longitudinal (temporal) effect of wall shear stress (WSS) on remodeling process of AVFs with two different configurations. The hypothesis is that early assessment of hemodynamic endpoints such as temporal gradient of WSS will predict the maturation status of AVF at later time points. Two AVFs with curved (C-AVF) and straight (S-AVF) configurations were created between the femoral artery and vein of each pig. Three pigs were considered in this study and in total six AVFs (three C-AVF and three S-AVF) were created. The CT scan and ultrasound were utilized to numerically evaluate local WSS at 20 cross-sections along the venous segment of AVFs at 2D (D: days), 7D, and 28D postsurgery. These cross-sections were located at 1.5 mm increments from the anastomosis junction. Local WSS values at these cross-sections were correlated with their corresponding luminal area over time. The WSS in C-AVF decreased from 22.3 ± 4.8 dyn/cm(2) at 2D to 4.1 ± 5.1 dyn/cm(2) at 28D, while WSS increased in S-AVF from 13.0 ± 5.0 dyn/cm(2) at 2D to 36.7 ± 5.3 dyn/cm(2) at 28D. Corresponding to these changes in WSS levels, luminal area of C-AVF dilated (0.23 ± 0.14 cm(2) at 2D to 0.87 ± 0.14 cm(2) at 28D) with attendant increase in flow rate. However, S-AVF had minimal changes in area (0.26 ± 0.02 cm(2) at 2D to 0.27 ± 0.03 cm(2) at 28D) despite some increase in flow rate. Our results suggest that the temporal changes of WSS could have significant effects on AVF maturation. Reduction in WSS over time (regardless of initial values) may result in dilation (p < 0.05), while increase in WSS may be detrimental to maturation. Thus, creation of AVFs in a specific configuration which results in a decline in WSS over time may reduce AVF maturation failure.
Authors:
Ehsan Rajabi-Jagahrgh; Mahesh K Krishnamoorthy; Prabir Roy-Chaudhury; Paul Succop; Yang Wang; Ann Choe; Rupak K Banerjee
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-14
Journal Detail:
Title:  Seminars in dialysis     Volume:  26     ISSN:  1525-139X     ISO Abbreviation:  Semin Dial     Publication Date:    2013 Mar-Apr
Date Detail:
Created Date:  2013-03-25     Completed Date:  2013-09-19     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-15     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteriovenous Shunt, Surgical / methods*
Blood Flow Velocity
Endpoint Determination
Femoral Artery
Femoral Vein
Hemodynamics
Longitudinal Studies
Models, Animal
Regression Analysis
Renal Dialysis
Swine
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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