Document Detail


A longitudinal analysis of the relations among stress, depressive symptoms, leisure satisfaction, and endothelial function in caregivers.
MedLine Citation:
PMID:  22486550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Stress and depressive symptoms have been associated with impaired endothelial function as measured by brachial artery flow-mediated dilation (FMD), possibly through repeated and heightened activation of the sympathetic nervous system. Behavioral correlates of depression, such as satisfaction with leisure activities (i.e., leisure satisfaction), may also be associated with endothelial function via their association with depressive symptoms. This study examined the longitudinal associations between stress, depressive symptoms, leisure satisfaction, and endothelial function as measured by FMD.
METHOD: Participants were 116 older Alzheimer's caregivers (M age = 74.3 ± 8.1; 68% women; 87% white) who underwent 3 yearly assessments of FMD, stress, depressive symptoms, and leisure satisfaction. Mixed-regression analyses were used to examine longitudinal relationships between constructs of interest.
RESULTS: A significant and positive association was found between leisure satisfaction and FMD (p = .050), whereas a negative relationship was found for stress (p = .017). Depressive symptoms were not associated with FMD (p = .432). Time (p < .001) and the number of years caregiving (p = .027) were also significant predictors of FMD, suggesting that FMD decreased over time and was worse the longer a participant had been a caregiver prior to study enrollment.
CONCLUSIONS: These results suggest that behavioral correlates of depression (i.e., engagement in pleasurable activities) may be related to endothelial function in caregivers, and behavioral treatments for depression may be particularly useful in improving cardiovascular outcomes in caregivers.
Authors:
Brent T Mausbach; Elizabeth Chattillion; Susan K Roepke; Michael G Ziegler; Milos Milic; Roland von Känel; Joel E Dimsdale; Paul J Mills; Thomas L Patterson; Matthew A Allison; Sonia Ancoli-Israel; Igor Grant
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-09
Journal Detail:
Title:  Health psychology : official journal of the Division of Health Psychology, American Psychological Association     Volume:  31     ISSN:  1930-7810     ISO Abbreviation:  Health Psychol     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-10     Completed Date:  2012-10-19     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  8211523     Medline TA:  Health Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  433-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / nursing
Brachial Artery / physiopathology
Caregivers / psychology*
Depression / physiopathology*
Endothelium, Vascular / physiopathology
European Continental Ancestry Group
Female
Humans
Leisure Activities
Longitudinal Studies
Male
Personal Satisfaction
Regression Analysis
Stress, Psychological*
Grant Support
ID/Acronym/Agency:
AG 03090/AG/NIA NIH HHS; AG 15301/AG/NIA NIH HHS; R01 AG015301/AG/NIA NIH HHS; R01 AG031090/AG/NIA NIH HHS; R25 MH080916/MH/NIMH NIH HHS
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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