| Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure. | |
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MedLine Citation:
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PMID: 19667293 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We characterized the raltegravir (RAL) susceptibility and the integrase (IN)-mediated replication capacity (RC) of RAL-resistant human immunodeficiency virus type 1 from two patients experiencing virologic failure during continuous RAL salvage therapy. The following two distinct outcomes were observed: (i) the selective outgrowth of virus with high-level RAL resistance and high IN-mediated RC leading to significant viral load rebound and (ii) the selection of virus with a slight reduction in RAL susceptibility and low IN-mediated RC resulting in sustained low-level viremia. |
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Authors:
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Signe Fransen; Marina Karmochkine; Wei Huang; Laurence Weiss; Christos J Petropoulos; Charlotte Charpentier |
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Publication Detail:
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Type: Journal Article Date: 2009-08-10 |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 53 ISSN: 1098-6596 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-22 Completed Date: 2009-12-14 Revised Date: 2010-09-27 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: United States |
Other Details:
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Languages: eng Pagination: 4522-4 Citation Subset: IM |
Affiliation:
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Monogram Biosciences, South San Francisco, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Drug Resistance, Viral / genetics HIV Integrase Inhibitors / pharmacology* HIV-1 / drug effects*, enzymology Humans Pyrrolidinones / pharmacology* Virus Replication / drug effects |
| Chemical | |
Reg. No./Substance:
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0/HIV Integrase Inhibitors; 0/MK 0518; 0/Pyrrolidinones |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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