Document Detail


Longitudinal analysis of neural network development in preterm infants.
MedLine Citation:
PMID:  20237243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Application of resting state functional connectivity magnetic resonance imaging (fcMRI) to the study of prematurely born infants enables assessment of the earliest forms of cerebral connectivity and characterization of its early development in the human brain. We obtained 90 longitudinal fcMRI data sets from a cohort of preterm infants aged from 26 weeks postmenstrual age (PMA) through term equivalent age at PMA-specific time points. Utilizing seed-based correlation analysis, we identified resting state networks involving varied cortical regions, the thalamus, and cerebellum. Identified networks demonstrated a regionally variable age-specific pattern of development, with more mature forms consisting of localized interhemispheric connections between homotopic counterparts. Anatomical distance was found to play a critical role in the rate of connection development. Prominent differences were noted between networks identified in term control versus premature infants at term equivalent, including in the thalamocortical connections critical for neurodevelopment. Putative precursors of the default mode network were detected in term control infants but were not identified in preterm infants, including those at term equivalent. Identified patterns of network maturation reflect the intricate relationship of structural and functional processes present throughout this important developmental period and are consistent with prior investigations of neurodevelopment in this population.
Authors:
Christopher D Smyser; Terrie E Inder; Joshua S Shimony; Jason E Hill; Andrew J Degnan; Abraham Z Snyder; Jeffrey J Neil
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-03-17
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  20     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2011-03-01     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2852-62     Citation Subset:  IM    
Affiliation:
Department of Neurology, Division of Pediatric Neurology, Washington University School ofMedicine, 660 South Euclid Avenue, Saint Louis, MO 63110-1093, USA. smyserc@neuro.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Brain / growth & development*
Female
Humans
Image Interpretation, Computer-Assisted
Infant, Newborn / growth & development*
Magnetic Resonance Imaging
Male
Nerve Net / growth & development*
Neurogenesis*
Pregnancy
Premature Birth
Grant Support
ID/Acronym/Agency:
K23 HD053212/HD/NICHD NIH HHS; P30 NS048056/NS/NINDS NIH HHS; R01 HD05709801/HD/NICHD NIH HHS
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