Document Detail


Longitudinal 1H MRS of rat forebrain from infancy to adulthood reveals adolescence as a distinctive phase of neurometabolite development.
MedLine Citation:
PMID:  23322706     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study represents the first longitudinal, within-subject (1) H MRS investigation of the developing rat brain spanning infancy, adolescence and early adulthood. We obtained neurometabolite profiles from a voxel located in a central location of the forebrain, centered on the striatum, with smaller contributions for the cortex, thalamus and hypothalamus, on postnatal days 7, 35 and 60. Water-scaled metabolite signals were corrected for T1 effects and quantified using the automated processing software LCModel, yielding molal concentrations. Our findings indicate age-related concentration changes in N-acetylaspartate + N-acetylaspartylglutamate, myo-inositol, glutamate + glutamine, taurine, creatine + phosphocreatine and glycerophosphocholine + phosphocholine. Using a repeated measures design and analysis, we identified significant neurodevelopment changes across all three developmental ages and identified adolescence as a distinctive phase in normative neurometabolic brain development. Between postnatal days 35 and 60, changes were observed in the concentrations of N-acetylaspartate + N-acetylaspartylglutamate, glutamate + glutamine and glycerophosphocholine + phosphocholine. Our data replicate past studies of early neurometabolite development and, for the first time, link maturational profiles in the same subjects across infancy, adolescence and adulthood.
Authors:
Jonathan J Morgan; Gale A Kleven; Christina D Tulbert; John Olson; David A Horita; April E Ronca
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-16
Journal Detail:
Title:  NMR in biomedicine     Volume:  26     ISSN:  1099-1492     ISO Abbreviation:  NMR Biomed     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-04-23     Completed Date:  2013-11-08     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  8915233     Medline TA:  NMR Biomed     Country:  England    
Other Details:
Languages:  eng     Pagination:  683-91     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Aspartic Acid / analogs & derivatives,  metabolism
Dipeptides / metabolism
Glutamic Acid / metabolism
Inositol / metabolism
Magnetic Resonance Spectroscopy / methods*
Male
Phosphocreatine / metabolism
Prosencephalon / growth & development,  metabolism*
Rats
Rats, Sprague-Dawley
Taurine / metabolism
Grant Support
ID/Acronym/Agency:
HD050201/HD/NICHD NIH HHS; HD057488/HD/NICHD NIH HHS; R01 HD050201/HD/NICHD NIH HHS; R21 HD057488/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Dipeptides; 020IUV4N33/Phosphocreatine; 1EQV5MLY3D/Taurine; 30KYC7MIAI/Aspartic Acid; 3106-85-2/N-acetyl-1-aspartylglutamic acid; 3KX376GY7L/Glutamic Acid; 4L6452S749/Inositol; 997-55-7/N-acetylaspartate
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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