| Longevity-fertility trade-offs in the tephritid fruit fly, Anastrepha ludens, across dietary-restriction gradients. | |
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MedLine Citation:
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PMID: 18346215 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although it is widely known that dietary restriction (DR) not only extends the longevity of a wide range of species but also reduces their reproductive output, the interrelationship of DR, longevity extension and reproduction is not well understood in any organism. Here we address the question: 'Under what nutritional conditions do the longevity-enhancing effects resulting from food restriction either counteract, complement or reinforce the mortality costs of reproduction? To answer this question we designed a fine-grained DR study involving 4800 individuals of the tephritid fruit fly, Anastrepha ludens, in which we measured sex-specific survival and daily reproduction in females in each of 20 different treatments (sugar : yeast ratios) plus 4 starvation controls. The database generated from this 3-year study consisted of approximately 100 000 life-days for each sex and 750 000 eggs distributed over the reproductive lives of 2400 females. The fertility and longevity-extending responses were used to create contour maps (X-Y grid) that show the demographic responses (Z-axis) across dietary gradients that range from complete starvation to both ad libitum sugar-only and ad libitum standard diet (3 : 1 sugar : yeast). The topographic perspectives reveal demographic equivalencies along nutritional gradients, differences in the graded responses of males and females, egg production costs that are sensitive to the interaction of food amounts and constituents, and orthogonal contours (equivalencies in longevity or reproduction) representing demographic thresholds related to both caloric content and sugar : yeast ratios. In general, the finding that lifespan and reproductive maxima occur at much different nutritional coordinates poses a major challenge for the use of food restriction (or a mimetic) in humans to improve health and extend longevity in humans. |
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Authors:
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James R Carey; Lawrence G Harshman; Pablo Liedo; Hans-Georg Müller; Jane-Ling Wang; Zhen Zhang |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-03-11 |
Journal Detail:
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Title: Aging cell Volume: 7 ISSN: 1474-9726 ISO Abbreviation: Aging Cell Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-18 Completed Date: 2008-10-09 Revised Date: 2012-10-09 |
Medline Journal Info:
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Nlm Unique ID: 101130839 Medline TA: Aging Cell Country: England |
Other Details:
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Languages: eng Pagination: 470-7 Citation Subset: IM |
Affiliation:
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Department of Entomology, University of California, Davis, Davis, CA 95616, USA. jrcarey@ucdavis.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caloric Restriction* Diet* Female Fertility / physiology Longevity / physiology* Male Ovum / physiology Survival Analysis Tephritidae / physiology* Yeasts |
| Grant Support | |
ID/Acronym/Agency:
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P01 AG008761/AG/NIA NIH HHS; P01 AG008761-170003/AG/NIA NIH HHS; P01 AG022500-01/AG/NIA NIH HHS; P01 AG022500-01/AG/NIA NIH HHS; P01 AG08761-10/AG/NIA NIH HHS; R01 AG025218/AG/NIA NIH HHS |
| Comments/Corrections | |
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