Document Detail

Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population.
MedLine Citation:
PMID:  14688809     Owner:  NLM     Status:  MEDLINE    
It has been reported that the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism, also called NADH dehydrogenase subunit 2-237 methionine/leucine (ND2-237 Met/Leu) polymorphism, may be associated with longevity in Japanese individuals, and that the mt5178A genotype may have an antiatherogenic influence. To determine whether mt5178 A/C polymorphism influences blood pressure, we genotyped 412 healthy Japanese individuals and performed a cross-sectional study investigating the relationship between genotype and blood pressure. In women with mt5178A, the mean diastolic blood pressure was higher than in those with mt5178C by 3.2 mmHg (P=0.040). In men, no statistically significant difference in systolic or diastolic blood pressure was observed between mt5178 A/C genotypes. However, a significant correlation between mt5178 A/C genotypes and the effects of habitual drinking on blood pressure was found. After adjustment for several factors, in men carrying mt5178C, both systolic and diastolic blood pressure were significantly higher in daily drinkers than in occasional (P=0.002 and 0.002, respectively) as well as nondrinkers (P<0.001 and 0.001, respectively), whereas in men carrying mt5178A, no significant differences in blood pressure were detected, irrespective of alcohol consumption. These results suggest that mt5178 A/C (=ND2-237 Met/Leu) polymorphism may influence both diastolic blood pressure in Japanese women and the blood-pressure-increasing effect of drinking in Japanese men.
A Kokaze; M Ishikawa; N Matsunaga; M Yoshida; Y Sekine; K Sekiguchi; M Harada; M Satoh; K Teruya; N Takeda; S Fukazawa; Y Uchida; Y Takashima
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of human hypertension     Volume:  18     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  41-5     Citation Subset:  IM    
Copyright Information:
Journal of Human Hypertension (2004) 18, 41-45. doi:10.1038/sj.jhh.1001632
Department of Public Health, Kyorin University School of Medicine, Shinkawa Mitaka-shi, Tokyo, Japan.
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MeSH Terms
Alcohol Drinking / genetics
Blood Pressure*
Cross-Sectional Studies
DNA, Mitochondrial / genetics*
Longevity / genetics*
Middle Aged
NADH Dehydrogenase / genetics*
Polymorphism, Genetic
Reg. No./Substance:
0/DNA, Mitochondrial; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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