Document Detail

Long-term within-subject variability of inspiratory neural drive response to hypoxia.
MedLine Citation:
PMID:  9726740     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. PATIENTS AND INTERVENTIONS: We studied 21 healthy subjects (14 male and 7 female; aged 40+/-12 yrs) (mean+/-SD). Lung volumes, basal P0.1, and P0.1 response to hypoxia were measured on two separate occasions 2 months apart, under similar ambient and clinical conditions. RESULTS: There was no significant change in clinical condition, FVC, FEV1, arterial oxygenation saturation, end-tidal and mixed venous PCO2 levels, or P0.1 between the two visits. The mean P0.1 responses to hypoxia in the two explorations were 0.032+/-0.022 and 0.034+/-0.022 kPa/%, respectively. There was a moderate intrasubject variability of P0.1 response to hypoxia, with a coefficient of reproducibility of 0.01 kPa/%. Power calculations to establish the optimal sample size required for hypoxic stimulation are presented. CONCLUSION: Long term within-subject variability of P0.1 response to hypoxia is moderate. This intrinsic variability needs to be emphasized when interpreting the effects of experimental interventions on hypoxic sensitivity.
F García-Río; J M Pino-García; M A Racionero; J G Terreros-Caro; M A Gómez-Mendieta; C Prados; C Villasante
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chest     Volume:  114     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1998-09-15     Completed Date:  1998-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  521-5     Citation Subset:  AIM; IM    
Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain.
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MeSH Terms
Air Pressure
Anoxia / physiopathology*
Follow-Up Studies
Motor Neurons / physiology*
Mouth / physiology
Reproducibility of Results
Respiration / physiology*
Respiratory Center / physiology*
Respiratory Function Tests

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