| Long-term within-subject variability of inspiratory neural drive response to hypoxia. | |
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MedLine Citation:
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PMID: 9726740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVE: We analyze the within-subject variation of mouth occlusion pressure (P0.1) response to progressive isocapnic hypoxic stimulation over long time periods in normal subjects. PATIENTS AND INTERVENTIONS: We studied 21 healthy subjects (14 male and 7 female; aged 40+/-12 yrs) (mean+/-SD). Lung volumes, basal P0.1, and P0.1 response to hypoxia were measured on two separate occasions 2 months apart, under similar ambient and clinical conditions. RESULTS: There was no significant change in clinical condition, FVC, FEV1, arterial oxygenation saturation, end-tidal and mixed venous PCO2 levels, or P0.1 between the two visits. The mean P0.1 responses to hypoxia in the two explorations were 0.032+/-0.022 and 0.034+/-0.022 kPa/%, respectively. There was a moderate intrasubject variability of P0.1 response to hypoxia, with a coefficient of reproducibility of 0.01 kPa/%. Power calculations to establish the optimal sample size required for hypoxic stimulation are presented. CONCLUSION: Long term within-subject variability of P0.1 response to hypoxia is moderate. This intrinsic variability needs to be emphasized when interpreting the effects of experimental interventions on hypoxic sensitivity. |
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Authors:
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F García-Río; J M Pino-García; M A Racionero; J G Terreros-Caro; M A Gómez-Mendieta; C Prados; C Villasante |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Chest Volume: 114 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1998-09-15 Completed Date: 1998-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 521-5 Citation Subset: AIM; IM |
Affiliation:
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Servicio de Neumología, Hospital Universitario La Paz, Madrid, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pressure Anoxia / physiopathology* Female Follow-Up Studies Humans Male Motor Neurons / physiology* Mouth / physiology Reproducibility of Results Respiration / physiology* Respiratory Center / physiology* Respiratory Function Tests |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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