| Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice. | |
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MedLine Citation:
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PMID: 22052204 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To determine the impact of long-term voluntary exercise, representing habitual exercise for the prevention of lifestyle-related diseases, on glucose, lipid, and amino acid metabolism in mice. METHODS: Twenty-four mice aged 6 weeks were divided into three groups. Two groups (16 mice) were housed individually in either cages equipped with a running wheel (8 mice, exercising, Ex-mice) or without (8 mice, sedentary, Se-mice) for 24 weeks. The remaining group (8 mice) was sacrificed at 6 weeks of age. Biomarkers related to glucose, lipid, and amino acid metabolism were examined. RESULTS: Ex-mice ran voluntarily, predominantly in the dark. The distance per day peaked at 4 weeks and then decreased until 12 weeks to around the level seen at the beginning of the experimental period, and was maintained at 4.9 ± 0.2 km/day from 12 to 24 weeks. Ex-mice showed a similar adrenal weight and vitamin C content to Se-mice but had a significantly lower body weight and higher food intake. Ex-mice also showed a higher skeletal muscle weight, a lower white adipose tissue and liver weight, associated with lower plasma leptin and insulin-like growth factor-1 levels, and a lower hepatic triglyceride content. Analysis of plasma amino acids showed that Ex-mice had significantly higher phenylalanine, tyrosine, and glutamine levels, resulting in a significantly lower Fischer's ratio. CONCLUSIONS: We present an animal model of long-term voluntary exercise under low stress. Findings related to the effects of long-term voluntary exercise on lipid, and amino acid metabolism in our mouse model indicate that such an exercise regimen may affect pathophysiological states related to appetite and behavior. |
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Authors:
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Haruko Takeshita; Masahisa Horiuchi; Kimiko Izumo; Hiroaki Kawaguchi; Emi Arimura; Kohji Aoyama; Toru Takeuchi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-11-04 |
Journal Detail:
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Title: Environmental health and preventive medicine Volume: 17 ISSN: 1347-4715 ISO Abbreviation: Environ Health Prev Med Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-06 Completed Date: 2012-11-01 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9609642 Medline TA: Environ Health Prev Med Country: Japan |
Other Details:
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Languages: eng Pagination: 275-84 Citation Subset: IM |
Affiliation:
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Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Amino Acids / blood* Animals Blood Glucose / metabolism* Body Composition Eating Female Gene Expression Regulation Lipid Metabolism* Liver / metabolism Mice Models, Animal Physical Exertion* Polymerase Chain Reaction RNA, Messenger / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Blood Glucose; 0/RNA, Messenger |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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