Document Detail

Long-term voluntary exercise, representing habitual exercise, lowers visceral fat and alters plasma amino acid levels in mice.
MedLine Citation:
PMID:  22052204     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the impact of long-term voluntary exercise, representing habitual exercise for the prevention of lifestyle-related diseases, on glucose, lipid, and amino acid metabolism in mice.
METHODS: Twenty-four mice aged 6 weeks were divided into three groups. Two groups (16 mice) were housed individually in either cages equipped with a running wheel (8 mice, exercising, Ex-mice) or without (8 mice, sedentary, Se-mice) for 24 weeks. The remaining group (8 mice) was sacrificed at 6 weeks of age. Biomarkers related to glucose, lipid, and amino acid metabolism were examined.
RESULTS: Ex-mice ran voluntarily, predominantly in the dark. The distance per day peaked at 4 weeks and then decreased until 12 weeks to around the level seen at the beginning of the experimental period, and was maintained at 4.9 ± 0.2 km/day from 12 to 24 weeks. Ex-mice showed a similar adrenal weight and vitamin C content to Se-mice but had a significantly lower body weight and higher food intake. Ex-mice also showed a higher skeletal muscle weight, a lower white adipose tissue and liver weight, associated with lower plasma leptin and insulin-like growth factor-1 levels, and a lower hepatic triglyceride content. Analysis of plasma amino acids showed that Ex-mice had significantly higher phenylalanine, tyrosine, and glutamine levels, resulting in a significantly lower Fischer's ratio.
CONCLUSIONS: We present an animal model of long-term voluntary exercise under low stress. Findings related to the effects of long-term voluntary exercise on lipid, and amino acid metabolism in our mouse model indicate that such an exercise regimen may affect pathophysiological states related to appetite and behavior.
Haruko Takeshita; Masahisa Horiuchi; Kimiko Izumo; Hiroaki Kawaguchi; Emi Arimura; Kohji Aoyama; Toru Takeuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-04
Journal Detail:
Title:  Environmental health and preventive medicine     Volume:  17     ISSN:  1347-4715     ISO Abbreviation:  Environ Health Prev Med     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-06     Completed Date:  2012-11-01     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9609642     Medline TA:  Environ Health Prev Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  275-84     Citation Subset:  IM    
Department of Environmental Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.
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MeSH Terms
Adipose Tissue / metabolism
Amino Acids / blood*
Blood Glucose / metabolism*
Body Composition
Gene Expression Regulation
Lipid Metabolism*
Liver / metabolism
Models, Animal
Physical Exertion*
Polymerase Chain Reaction
RNA, Messenger / metabolism
Time Factors
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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