Document Detail

Long-term voluntary exercise and the mouse hypothalamic-pituitary-adrenocortical axis: impact of concurrent treatment with the antidepressant drug tianeptine.
MedLine Citation:
PMID:  17076767     Owner:  NLM     Status:  MEDLINE    
We investigated whether voluntary exercise and concurrent antidepressant treatment (tianeptine; 20 mg/kg/day; 4 weeks) exert synergistic effects on the mouse hypothalamic-pituitary-adrenocortical (HPA) axis. Animals had access to a running wheel, were treated with the antidepressant, or received both conditions combined. Control mice received no running wheel and no drug treatment. Exercise resulted in asymmetric changes in the adrenal glands. Whereas sedentary mice had larger left adrenals than right ones, this situation was abolished in exercising animals, mainly due to enlargement of the right adrenal cortex. However, antidepressant treatment alone was ineffective whereas the combination of antidepressant treatment and exercise resulted in an enlargement of both adrenal cortices. In these respective conditions, the levels of tyrosine hydroxylase (TH) mRNA expression in the left and right adrenal medullas varied greatly in parallel to the changes observed in the adrenal cortex sizes. TH mRNA expression in the locus coeruleus of exercising mice was significantly increased irrespective of concomitant tianeptine treatment. Corticotrophin-releasing factor mRNA levels in the hypothalamic paraventricular nucleus were decreased after voluntary exercise but were unaffected by tianeptine. Exercise, particularly in combination with tianeptine treatment, resulted in decreased early morning baseline plasma levels of corticosterone. If animals were exposed to novelty (i.e. a mild psychological stressor), a decreased response in plasma corticosterone levels was observed in the exercising mice. By contrast, after restraint, a mixed physical and psychological stressor, exercising mice showed an enhanced response in plasma corticosterone compared to the controls; a response which was even further boosted in exercising mice concomitantly treated with tianeptine. Under either condition, plasma adrenocorticotrophic hormone levels were not different between groups. Thus, voluntary exercise impacts substantially on HPA axis regulation. Concurrent tianeptine treatment results in synergistic actions, mainly at the adrenal level, affecting both its structure and function.
S K Droste; M C Schweizer; S Ulbricht; J M H M Reul
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  18     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-01     Completed Date:  2007-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  915-25     Citation Subset:  IM    
Max Planck Institute of Psychiatry, Section of Neuropsychopharmacology, Munich, Germany.
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MeSH Terms
Adrenal Cortex / anatomy & histology,  drug effects,  physiology
Analysis of Variance
Antidepressive Agents, Tricyclic / pharmacology*
Choice Behavior
Circadian Rhythm / drug effects
Corticosterone / blood
Corticotropin-Releasing Hormone / genetics,  metabolism
Hypothalamo-Hypophyseal System / drug effects*,  metabolism
Locus Coeruleus / drug effects,  metabolism
Mice, Inbred C57BL
Organ Size
Paraventricular Hypothalamic Nucleus / drug effects,  metabolism
Physical Conditioning, Animal / physiology*
Pituitary-Adrenal System / drug effects*,  metabolism
RNA, Messenger / analysis
Thiazepines / pharmacology*
Time Factors
Tyrosine 3-Monooxygenase / genetics,  metabolism
Reg. No./Substance:
0/Antidepressive Agents, Tricyclic; 0/RNA, Messenger; 0/Thiazepines; 50-22-6/Corticosterone; 66981-73-5/tianeptine; 9015-71-8/Corticotropin-Releasing Hormone; EC 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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