Document Detail


Long-term use of topical calcipotriol in chronic plaque psoriasis.
MedLine Citation:
PMID:  7949479     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND DESIGN: A multi-centre, open, prospective study of 12 months duration was performed to assess safety, efficacy and tolerability of topical calcipotriol in the long-term treatment of psoriasis. One hundred and sixty-seven adults with chronic plaque psoriasis who had previously responded to calcipotriol entered the study. Disease activity was monitored using the psoriasis area and severity index (PASI). Calcipotriol ointment 50 micrograms/g was applied twice daily until remission was attained. Treatment was then stopped but reinstituted in the event of relapses. RESULTS: Of the 167 recruited patients, 6 patients did not receive any treatment during the trial. A total of 39 patients were withdrawn: 15 due to inadequate control of their psoriasis, 9 due to irritant reactions, 7 due to defaulting and 8 for miscellaneous voluntary reasons. A further 24 patients either reached the study medication limit of 2,500 g or were considered to have completed the study a few weeks prior to the 12-month period. Accordingly, 98 patients were assessable after 12 months of therapy. Complete clearing was obtained in 26% of subjects, who then used the treatment intermittently. The remaining patients required continuous treatment for 12 months. The mean PASI fell from 8.1 (SD +/- 6.67, n = 167) at baseline to 3.90 (+/- 3.50, 136) at 2 months and 2.71 (+/- 2.12, 98) at 12 months. There was no rise in the mean serum total calcium. CONCLUSION: Calcipotriol ointment was safe, effective and well tolerated.
Authors:
C A Ramsay; J Berth-Jones; G Brundin; W J Cunliffe; L Dubertret; P C van de Kerkhof; T Menne; E Wegmann
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Dermatology (Basel, Switzerland)     Volume:  189     ISSN:  1018-8665     ISO Abbreviation:  Dermatology (Basel)     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-02     Completed Date:  1994-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9203244     Medline TA:  Dermatology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  260-4     Citation Subset:  IM    
Affiliation:
University of Toronto, Ont., Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Adult
Aged
Aged, 80 and over
Calcitriol / administration & dosage,  adverse effects,  analogs & derivatives*
Chronic Disease
Dermatologic Agents / administration & dosage*,  adverse effects
Female
Humans
Male
Middle Aged
Ointments
Patient Compliance
Prospective Studies
Psoriasis / drug therapy*
Chemical
Reg. No./Substance:
0/Dermatologic Agents; 0/Ointments; 112965-21-6/calcipotriene; 32222-06-3/Calcitriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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