| Long-term use of gabapentin for treatment of pain after traumatic spinal cord injury. | |
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MedLine Citation:
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PMID: 11882775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the long-term efficacy of gabapentin as a treatment of pain after spinal cord injury. DESIGN: All patients with traumatic-onset spinal cord injury treated with gabapentin were identified and followed up using a longitudinal observational design with two contact points (6 and 36 months after the trial) using a semi-structured interview. The first follow-up interview attempted to capture all 31 patients placed on therapeutic trial. The second follow-up interview attempted to capture those reporting a favorable response (n = 14) to the therapeutic trial at the first follow-up. RESULTS: Of the 27 patients contacted at the first follow-up (87% response rate), 6 (22%) discontinued the trial secondary to intolerable side effects; therefore, the pain analgesic effects of gabapentin in these patients could not be determined. Of the remaining 21 patients, 14 (67%) reported a favorable response (i.e., a 2 or greater point reduction on a 0-10 pain-rating scale). The second follow-up interview captured 11 (79% response rate) of the 14 patients reporting a favorable response at the first interview, and 91% (10 of 11 patients) continued to report that gabapentin was an effective analgesic. There was no evidence to suggest dosing difficulties due to tolerance over the 3-year period. Sedation, dizziness, and forgetfulness were the most common side effects. CONCLUSIONS: Gabapentin may be an effective treatment of pain after spinal cord injury among those able to tolerate initial and long-term side effects. |
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Authors:
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John David Putzke; J Scott Richards; Laura Kezar; B L Hicken; T J Ness |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Clinical journal of pain Volume: 18 ISSN: 0749-8047 ISO Abbreviation: Clin J Pain Publication Date: 2002 Mar-Apr |
Date Detail:
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Created Date: 2002-03-07 Completed Date: 2002-05-30 Revised Date: 2013-06-11 |
Medline Journal Info:
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Nlm Unique ID: 8507389 Medline TA: Clin J Pain Country: United States |
Other Details:
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Languages: eng Pagination: 116-21 Citation Subset: IM |
Affiliation:
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Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, Alabama, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetates
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administration & dosage* Amines* Analgesics / administration & dosage Chronic Disease Cyclohexanecarboxylic Acids* Female Follow-Up Studies Humans Interviews as Topic / methods Longitudinal Studies Male Pain / drug therapy*, etiology Pain Measurement / methods Paraplegia / complications Spinal Cord Injuries / complications* gamma-Aminobutyric Acid* |
| Grant Support | |
ID/Acronym/Agency:
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T32 HD7420-10/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Acetates; 0/Amines; 0/Analgesics; 0/Cyclohexanecarboxylic Acids; 56-12-2/gamma-Aminobutyric Acid; 6CW7F3G59X/gabapentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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