Document Detail

[Long-term use of fondaparinux in major orthopedic surgery].
MedLine Citation:
PMID:  23145762     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: This study aims to investigate whether the usage of fondaparinux sodium may result in major hemorrhages following major orthopedic surgery.
PATIENTS AND METHODS: Forty-three patients (30 females and 13 males; mean age 66 years; range 34 to 94 years) at the age of >18 years who were scheduled for major orthopedic surgery were included. Total hip arthroplasty, total knee arthroplasty and proximal femur fracture surgeries were defined as the major orthopedic surgeries. Prophylaxis was administered with 2.5 mg fondaparinux sodium once daily subcutaneously. Prophylaxis was initiated at 6-8 hours after the closure of incision. During the prophylaxis period (31±3 days), the patients were monitored for symptomatic deep venous thrombosis. Serum creatinine, platelet and hemoglobin levels were measured at the baseline and in the first week and at one month postoperatively. Wound healing time, healing complications, and major/minor hemorrhages seen during the prophylaxis period were recorded.
RESULTS: During the follow-up, none of the patients had symptomatic deep vein thrombosis or symptomatic pulmonary embolism. Two patients (4.6%) had delayed wound healing, while four (9.3%) had minor ecchymosis. No major hemorrhages were observed in any patients.
CONCLUSION: With the long-term use of fondaparinux, we did not observe any major hemorrhagic complications. However, further large-scale studies including control groups are required to establish the effects of long-term use of fondaparinux.
Faik Altıntaş; Cağatay Uluçay; Ender Uğutmen; Melih Güven; Koray Unay
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Eklem hastalıkları ve cerrahisi = Joint diseases & related surgery     Volume:  23     ISSN:  1309-0313     ISO Abbreviation:  Eklem Hastalik Cerrahisi     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101265191     Medline TA:  Eklem Hastalik Cerrahisi     Country:  Turkey    
Other Details:
Languages:  tur     Pagination:  168-72     Citation Subset:  IM    
Department of Orthopedics and Traumatology, Medical Faculty of Yeditepe University, 34752 Kozyatağı, İstanbul, Turkey.
Vernacular Title:
Fondaparinuksun majör ortopedik cerrahide uzun süreli kullanımı
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