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Long-term use of doxycycline can improve chronic asthma and possibly remodeling: the result of a pilot observation.
MedLine Citation:
PMID:  22923997     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Chronic asthma shows progressive decline in lung function with reduction or even loss of reversibility secondary to remodeling. A set of endopeptidase enzymes known as matrix metalloproteinases are intimately related to the pathogenesis of asthma and remodeling. The inhibition of matrix metalloproteinases is recognized as a prospective way of treating asthma and its corresponding structural remodeling.
METHODS: In a randomized, prospective, real-world study, we have observed the change in lung function (spirometry) with an add-on of long-term doxycycline to standard asthma therapy as per the Global Initiative for Asthma guidelines in a small asthmatic population. The change in terms of forced expiratory volume (FEV(1)), forced vital capacity (FVC), percent of FEV(1) (FEV(1)%), and forced expiratory flow (FEF(25-75)) were noted following variable duration of doxycycline therapy.
RESULTS: There has been a global improvement in all the parameters in all the six patients suggesting improvement in obstruction, and reduction in air trapping following a treatment of add-on doxycycline for a mean duration of 162.83 ± 83.07 days. Of the changes seen, the post bronchodilator FEV(1), the FVC, and the FEF(25-75) showed significant improvements with the P-value set at 0.004, 0.054, and 0.031, respectively. There was also evidence of the reversal of remodeling from the improvement in the FEV(1)/FVC ratio. Moreover there was a greater than expected improvement of pre-bronchodilator FEV(1) after treatment that far surpassed the initial post-bronchodialator FEV(1) value. Even after such a change, there were presences of some reversibility suggesting room for further improvement.
CONCLUSION: The results suggest significant improvements in the obstructive parameters used to evaluate asthma, with possible reversal of remodeling evident in chronic asthmatics when treated with doxycycline in addition to standard therapies. This observation needs further scientific validation.
Parthasarathi Bhattacharyya; Rantu Paul; Partha Bhattacharjee; Arko Ghosh; Ratna Dey; Malabika Ghosh; Madan Sharma
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Publication Detail:
Type:  Journal Article     Date:  2012-08-08
Journal Detail:
Title:  Journal of asthma and allergy     Volume:  5     ISSN:  1178-6965     ISO Abbreviation:  J Asthma Allergy     Publication Date:  2012  
Date Detail:
Created Date:  2012-08-27     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101543450     Medline TA:  J Asthma Allergy     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  33-7     Citation Subset:  -    
Institute of Pulmocare and Research, CB 16, Salt Lake, Sector 1, Kolkata, India.
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