Document Detail

Long term use and abuse of benzodiazepines.
MedLine Citation:
PMID:  6108579     Owner:  NLM     Status:  MEDLINE    
1. We have stressed the detrimental effect that lay publications, T. V. and mass media has had on the pharmacotherapy of anxiety and depressive reactions with benzodiazepines. 2. We have reviewed the scientific literature and found few well documented cases of benzodiazepine dependence if one considers that benzodiazepines are the most prescribed medications. 3. We discussed the possibility that the seizures reported on withdrawal of benzodiazepines used for very long periods, is not a "proof" of a physical dependence, but rather clinical evidence of the well known anticonvulsant effect of benzodiazepines. 4. We have hypothesized that the withdrawal syndromes associated to high dosages of benzodiazepines might have a different neurochemical mechanism to that observed in alcohol and barbiturates withdrawals.
J Carranza
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmakopsychiatrie, Neuro-Psychopharmakologie     Volume:  13     ISSN:  0031-7098     ISO Abbreviation:  Pharmakopsychiatr Neuropsychopharmakol     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-02-19     Completed Date:  1981-02-19     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0146540     Medline TA:  Pharmakopsychiatr Neuropsychopharmakol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
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MeSH Terms
Anti-Anxiety Agents / adverse effects,  pharmacology,  therapeutic use*
Anxiety / drug therapy
Middle Aged
Substance Withdrawal Syndrome / psychology
Substance-Related Disorders / psychology*
gamma-Aminobutyric Acid / physiology
Reg. No./Substance:
0/Anti-Anxiety Agents; 12794-10-4/Benzodiazepines; 56-12-2/gamma-Aminobutyric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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