Document Detail

Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye.
MedLine Citation:
PMID:  11815344     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Several studies have reported that sodium hyaluronate is able to improve both symptoms and signs in patients with dry eye but none have demonstrated an improvement of conjunctival epithelial cell abnormalities of the ocular surface. The aim of this study was to explore the effect of sodium hyaluronate-containing eye drops on the ocular surface of patients with dry eye during long term treatment.
METHODS: A randomised double blind study was undertaken in 86 patients with medium to severe dry eye (that is, rose bengal and/or fluorescein test score of at least 3, tear film break up time <10 seconds, or Schirmer's test <5.5 mm). Patients were treated with either preservative-free sodium hyaluronate or saline for 3 months at a dose of one drop 4-8 times a day. Bulbar impression cytology, slit lamp examinations, and subjective symptoms were evaluated after 1, 2, and 3 months. Impression cytology was considered the primary efficacy parameter of the study.
RESULTS: The efficacy analysis was performed on a total of 44 patients who were able to fully adhere to the protocol. After 3 months of treatment sodium hyaluronate improved impression cytology score (p = 0.024 v baseline). At the same time also the difference with respect to placebo was statistically significant (p = 0.036). Study medication was well tolerated and no treatment related adverse events occurred during the study.
CONCLUSIONS: Sodium hyaluronate may effectively improve ocular surface damage associated with dry eye syndrome.
Pasquale Aragona; Vincenzo Papa; Antonio Micali; Marcello Santocono; Giovanni Milazzo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  86     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-01-29     Completed Date:  2002-03-07     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Institute of Ophthalmology, University of Messina, Italy.
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MeSH Terms
Double-Blind Method
Dry Eye Syndromes / drug therapy*,  pathology
Follow-Up Studies
Hyaluronic Acid / therapeutic use*
Middle Aged
Ophthalmic Solutions
Severity of Illness Index
Treatment Outcome
Reg. No./Substance:
0/Ophthalmic Solutions; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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