| Long-term treatment with intermitent intranasal or subcutaneous apormorphine in patients with levodopa-related motor fluctuations. | |
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MedLine Citation:
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PMID: 9197948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty patients with idiopathic Parkinson's disease and disabling motor fluctuations were treated with intermittent subcutaneous (11 patients) or intranasal (nine patients) apomorphine for > 2 years. Apomorphine significantly reduced the mean daily "off" hours in both groups (p < 0.01) and improved "off" dystonia and end-of-dose and diphasic diskinesias. Unlike others authors, we found no difference between intranasal and subcutaneous' groups of treatment in the mean dose of apomorphine required to turn "on." Tolerance phenomenon to apomorphine could not be demonstrated in the follow-up period. Nasal crusting and vestibulitis observed in some patients treated intranasally were the more severe side effects and determined that some of them either switched to subcutaneous therapy or abandoned the treatment. |
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Authors:
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J Esteban Muñoz; M J Martí; C Marín; E Tolosa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical neuropharmacology Volume: 20 ISSN: 0362-5664 ISO Abbreviation: Clin Neuropharmacol Publication Date: 1997 Jun |
Date Detail:
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Created Date: 1997-07-30 Completed Date: 1997-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7607910 Medline TA: Clin Neuropharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 245-52 Citation Subset: IM |
Affiliation:
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Servei de Neurologia, Hospital Clínic i Provincial de Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antiparkinson Agents / adverse effects*, therapeutic use* Apomorphine / therapeutic use* Female Humans Levodopa / adverse effects* Long-Term Care Male Middle Aged Motor Activity / drug effects Parkinson Disease / drug therapy, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Antiparkinson Agents; 0/Levodopa; 58-00-4/Apomorphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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