Document Detail

Long-term treatment with intermitent intranasal or subcutaneous apormorphine in patients with levodopa-related motor fluctuations.
MedLine Citation:
PMID:  9197948     Owner:  NLM     Status:  MEDLINE    
Twenty patients with idiopathic Parkinson's disease and disabling motor fluctuations were treated with intermittent subcutaneous (11 patients) or intranasal (nine patients) apomorphine for > 2 years. Apomorphine significantly reduced the mean daily "off" hours in both groups (p < 0.01) and improved "off" dystonia and end-of-dose and diphasic diskinesias. Unlike others authors, we found no difference between intranasal and subcutaneous' groups of treatment in the mean dose of apomorphine required to turn "on." Tolerance phenomenon to apomorphine could not be demonstrated in the follow-up period. Nasal crusting and vestibulitis observed in some patients treated intranasally were the more severe side effects and determined that some of them either switched to subcutaneous therapy or abandoned the treatment.
J Esteban Muñoz; M J Martí; C Marín; E Tolosa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  20     ISSN:  0362-5664     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-30     Completed Date:  1997-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  245-52     Citation Subset:  IM    
Servei de Neurologia, Hospital Clínic i Provincial de Barcelona, Spain.
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MeSH Terms
Antiparkinson Agents / adverse effects*,  therapeutic use*
Apomorphine / therapeutic use*
Levodopa / adverse effects*
Long-Term Care
Middle Aged
Motor Activity / drug effects
Parkinson Disease / drug therapy,  physiopathology
Reg. No./Substance:
0/Antiparkinson Agents; 0/Levodopa; 58-00-4/Apomorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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