| Long-term treatment with hyperbaric air improves hyperlipidemia of db/db mice. | |
| | |
MedLine Citation:
|
PMID: 20847521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperbaric air (HBA) is used to improve healing of wounds including diabetic ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism, were also attenuated by HBA treatment. These results suggest that exposure of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes mellitus. |
| | |
Authors:
|
Kiyoshi Teshigawara; Toshio Hosaka; Miwa Yamaguchi; Eri Terada; Yuka Kisyuku; Keiko Fukunaga; Yohko Hirata; Bayasgalan Jambaldorj; Nagakatsu Harada; Tohru Sakai; Yutaka Nakaya |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The journal of medical investigation : JMI Volume: 57 ISSN: 1349-6867 ISO Abbreviation: J. Med. Invest. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9716841 Medline TA: J Med Invest Country: Japan |
Other Details:
|
Languages: eng Pagination: 224-31 Citation Subset: IM |
Affiliation:
|
Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School, Tokushima, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Base Sequence Blood Glucose / metabolism Carnitine O-Palmitoyltransferase / genetics Chemokine CCL2 / genetics DNA Primers / genetics Diabetes Mellitus, Type 2 / metabolism, therapy Fatty Acids, Nonesterified / blood Humans Hyperbaric Oxygenation* Hyperlipidemias / genetics, metabolism, therapy* Insulin / blood Lipid Metabolism Male Mice Mice, Mutant Strains PPAR alpha / genetics RNA, Messenger / genetics, metabolism Trans-Activators / genetics Triglycerides / blood Tumor Necrosis Factor-alpha / genetics |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Ccl2 protein, mouse; 0/Chemokine CCL2; 0/DNA Primers; 0/Fatty Acids, Nonesterified; 0/PPAR alpha; 0/Ppargc1a protein, mouse; 0/RNA, Messenger; 0/Trans-Activators; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha; 11061-68-0/Insulin; EC 2.3.1.21/Carnitine O-Palmitoyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Identification of important regulatory region of Th-POK.
Next Document: Vascular endothelial growth factors and their receptors in the novel human cell line, HN-Eso-1, esta...