| Long-term treatment with the combination of amantadine and ribavirin in hepatitis C nonresponders. A case series. | |
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MedLine Citation:
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PMID: 17401686 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this report, we describe five cases of chronic hepatitis C that have been treated with the combination of amantadine and ribavirin for an average of 44 months, emphasizing one case where the patient showed improvement in liver biopsy after treatment, worsening on removal, then a repeated improvement with re-initiation. The five patients in this report belong to a pool of sixty patients from a 6 month pilot study using amantadine and ribavirin where treatment was subsequently continued. The mean ALT was 82.8+/-32 U/L pre-treatment and 33.8+/-17.3 U/L post-treatment (p=0.02). The mean Knodell score was 7+/-1 pre-treatment and 3.6+/-1.5 post-treatment (p=0.13). The mean viral load was 584,155+/-248,027 lU/ml pre-treatment and 225,878+/-190,143 IU/ml post-treatment (p=0.05). In this case series we provide provocative data on the long-term use of ribavirin and amantadine in the HCV non-responder. |
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Authors:
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Thomas R Riley; Mohammad R Taheri |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-03-31 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 52 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-11-08 Completed Date: 2007-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 3418-22 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Penn State University, The Hershey Medical Center, Hershey, Pennsylvania 17033, USA. triley@psu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amantadine
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administration & dosage,
therapeutic use* Antiviral Agents / administration & dosage, therapeutic use* Biopsy Dose-Response Relationship, Drug Drug Therapy, Combination Drug Tolerance Female Follow-Up Studies Hepacivirus / drug effects, genetics Hepatitis C, Chronic / drug therapy*, pathology Humans Male Middle Aged RNA, Viral / analysis Ribavirin / administration & dosage, therapeutic use* Time Factors Viral Load |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/RNA, Viral; 36791-04-5/Ribavirin; 768-94-5/Amantadine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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