Document Detail


Long-term treatment with the combination of amantadine and ribavirin in hepatitis C nonresponders. A case series.
MedLine Citation:
PMID:  17401686     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this report, we describe five cases of chronic hepatitis C that have been treated with the combination of amantadine and ribavirin for an average of 44 months, emphasizing one case where the patient showed improvement in liver biopsy after treatment, worsening on removal, then a repeated improvement with re-initiation. The five patients in this report belong to a pool of sixty patients from a 6 month pilot study using amantadine and ribavirin where treatment was subsequently continued. The mean ALT was 82.8+/-32 U/L pre-treatment and 33.8+/-17.3 U/L post-treatment (p=0.02). The mean Knodell score was 7+/-1 pre-treatment and 3.6+/-1.5 post-treatment (p=0.13). The mean viral load was 584,155+/-248,027 lU/ml pre-treatment and 225,878+/-190,143 IU/ml post-treatment (p=0.05). In this case series we provide provocative data on the long-term use of ribavirin and amantadine in the HCV non-responder.
Authors:
Thomas R Riley; Mohammad R Taheri
Related Documents :
16498326 - Chronic hepatitis c. new therapeutic strategies.
21120196 - Erratum.
16861096 - Long-term (120-week) antiviral efficacy and tolerability of fosamprenavir/ritonavir onc...
23844386 - Ionospheric anomalies related to the (m = 7.3), august 27, 2012, puerto earthquake, (m ...
21620776 - Fusion rates of a morselized local bone graft in polyetheretherketone cages in posterio...
21184996 - Comparison of the effectiveness and safety of low-molecular weight heparin versus unfra...
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-31
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  52     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3418-22     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Penn State University, The Hershey Medical Center, Hershey, Pennsylvania 17033, USA. triley@psu.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amantadine / administration & dosage,  therapeutic use*
Antiviral Agents / administration & dosage,  therapeutic use*
Biopsy
Dose-Response Relationship, Drug
Drug Therapy, Combination
Drug Tolerance
Female
Follow-Up Studies
Hepacivirus / drug effects,  genetics
Hepatitis C, Chronic / drug therapy*,  pathology
Humans
Male
Middle Aged
RNA, Viral / analysis
Ribavirin / administration & dosage,  therapeutic use*
Time Factors
Viral Load
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/RNA, Viral; 36791-04-5/Ribavirin; 768-94-5/Amantadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of oxidative stress in celecoxib-induced renal damage in wistar rats.
Next Document:  The role of smoking in Crohn's disease as defined by clinical variables.