Document Detail

Long-term treatment with the combination of amantadine and ribavirin in hepatitis C nonresponders. A case series.
MedLine Citation:
PMID:  17401686     Owner:  NLM     Status:  MEDLINE    
In this report, we describe five cases of chronic hepatitis C that have been treated with the combination of amantadine and ribavirin for an average of 44 months, emphasizing one case where the patient showed improvement in liver biopsy after treatment, worsening on removal, then a repeated improvement with re-initiation. The five patients in this report belong to a pool of sixty patients from a 6 month pilot study using amantadine and ribavirin where treatment was subsequently continued. The mean ALT was 82.8+/-32 U/L pre-treatment and 33.8+/-17.3 U/L post-treatment (p=0.02). The mean Knodell score was 7+/-1 pre-treatment and 3.6+/-1.5 post-treatment (p=0.13). The mean viral load was 584,155+/-248,027 lU/ml pre-treatment and 225,878+/-190,143 IU/ml post-treatment (p=0.05). In this case series we provide provocative data on the long-term use of ribavirin and amantadine in the HCV non-responder.
Thomas R Riley; Mohammad R Taheri
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-31
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  52     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-08     Completed Date:  2007-12-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3418-22     Citation Subset:  AIM; IM    
Department of Medicine, Penn State University, The Hershey Medical Center, Hershey, Pennsylvania 17033, USA.
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MeSH Terms
Amantadine / administration & dosage,  therapeutic use*
Antiviral Agents / administration & dosage,  therapeutic use*
Dose-Response Relationship, Drug
Drug Therapy, Combination
Drug Tolerance
Follow-Up Studies
Hepacivirus / drug effects,  genetics
Hepatitis C, Chronic / drug therapy*,  pathology
Middle Aged
RNA, Viral / analysis
Ribavirin / administration & dosage,  therapeutic use*
Time Factors
Viral Load
Reg. No./Substance:
0/Antiviral Agents; 0/RNA, Viral; 36791-04-5/Ribavirin; 768-94-5/Amantadine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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