Document Detail


Long-term treatment with 1 alpha-hydroxyvitamin D3 with calcium supplement in spinal osteoporotic patients.
MedLine Citation:
PMID:  1461825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The long-term effect of 1 alpha-hydroxyvitamin D3 and calcium lactate in osteoporotic patients was evaluated by the bone mineral density (BMD) measured at the distal one third and one sixth of the radius and by the vertebral fracture rate. Forty-five osteoporotic patients medicated for 1 to 13 years (treated group) and 11 osteoporotic patients with no medication for 1 to 3 years (control group) were compared. The BMD of the treated group remained unchanged for the first 4 (one-third site) and 6 years (one-sixth site), followed by significant decreases, whereas that of the control group decreased significantly at the second and third year. The effect on BMD was more prominent in the patients with lower initial BMD. The vertebral fracture rate of the treated group was significantly less than that in the control group at the third year. No serious side effects were recognized. Overall, we believe 1 alpha-hydroxyvitamin D3 with calcium supplement can be considered a safe and effective agent for long-term use in osteoporotic patients.
Authors:
E Itoi; Y Yamada; M Sakurai; K Sato; F Kasama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Orthopedics     Volume:  15     ISSN:  0147-7447     ISO Abbreviation:  Orthopedics     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-08     Completed Date:  1993-01-08     Revised Date:  2012-01-30    
Medline Journal Info:
Nlm Unique ID:  7806107     Medline TA:  Orthopedics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1409-14     Citation Subset:  IM    
Affiliation:
Department of Orthopedic Surgery, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Bone Density
Cytochrome P-450 CYP27A1
Female
Humans
Lactates / therapeutic use
Lactic Acid
Middle Aged
Osteoporosis / complications,  diagnosis,  drug therapy*
Spinal Diseases / drug therapy*
Spinal Fractures / etiology
Steroid Hydroxylases / therapeutic use*
Chemical
Reg. No./Substance:
0/Lactates; 50-21-5/Lactic Acid; EC 1.14.-/Cytochrome P-450 CYP27A1; EC 1.14.-/Steroid Hydroxylases; EC 1.14.13.15/CYP27A1 protein, human

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