| Long-term treatment with 1 alpha-hydroxyvitamin D3 with calcium supplement in spinal osteoporotic patients. | |
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MedLine Citation:
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PMID: 1461825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The long-term effect of 1 alpha-hydroxyvitamin D3 and calcium lactate in osteoporotic patients was evaluated by the bone mineral density (BMD) measured at the distal one third and one sixth of the radius and by the vertebral fracture rate. Forty-five osteoporotic patients medicated for 1 to 13 years (treated group) and 11 osteoporotic patients with no medication for 1 to 3 years (control group) were compared. The BMD of the treated group remained unchanged for the first 4 (one-third site) and 6 years (one-sixth site), followed by significant decreases, whereas that of the control group decreased significantly at the second and third year. The effect on BMD was more prominent in the patients with lower initial BMD. The vertebral fracture rate of the treated group was significantly less than that in the control group at the third year. No serious side effects were recognized. Overall, we believe 1 alpha-hydroxyvitamin D3 with calcium supplement can be considered a safe and effective agent for long-term use in osteoporotic patients. |
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Authors:
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E Itoi; Y Yamada; M Sakurai; K Sato; F Kasama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Orthopedics Volume: 15 ISSN: 0147-7447 ISO Abbreviation: Orthopedics Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-01-08 Completed Date: 1993-01-08 Revised Date: 2012-01-30 |
Medline Journal Info:
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Nlm Unique ID: 7806107 Medline TA: Orthopedics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1409-14 Citation Subset: IM |
Affiliation:
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Department of Orthopedic Surgery, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Bone Density Cytochrome P-450 CYP27A1 Female Humans Lactates / therapeutic use Lactic Acid Middle Aged Osteoporosis / complications, diagnosis, drug therapy* Spinal Diseases / drug therapy* Spinal Fractures / etiology Steroid Hydroxylases / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 50-21-5/Lactic Acid; EC 1.14.-/Cytochrome P-450 CYP27A1; EC 1.14.-/Steroid Hydroxylases; EC 1.14.13.15/CYP27A1 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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