Document Detail

Long-term treatment of trigeminal neuralgia with carbamazepine.
MedLine Citation:
PMID:  7279817     Owner:  NLM     Status:  MEDLINE    
The results of treating 143 patients with trigeminal neuralgia with carbamazepine (CBZ) over a 16-year period have been reviewed. The drug was effective initially with few mild side effects in 99 patients (69%). Of these, 19 developed resistance later, i.e. between 2 months and 10 years after commencing treatment, and required alternative measures. Of the remaining 80 (56%), the drug was effective in 49 for 1-4 years and in 31 for 5-16 years. Thirty-six patients (25%) failed to respond to CBZ initially and required alternative measures, as did 8 (6%) who were intolerant of the drug. One patient developed CBZ-induced water intoxication with hyponatraemia. Subsequently hyponatraemia was excluded in 17 patients who had been taking CBZ for between 4 months and 7 years. This study has thus confirmed the efficacy of CBZ in the treatment of trigeminal neuralgia and shown that it may continue to be effective for many years.
J C Taylor; S Brauer; M L Espir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  57     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1981 Jan 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  16-8     Citation Subset:  IM    
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MeSH Terms
Carbamazepine / administration & dosage,  adverse effects,  therapeutic use*
Drug Resistance
Middle Aged
Time Factors
Trigeminal Neuralgia / drug therapy*
Reg. No./Substance:

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