Document Detail


Long-term treatment of onchocerciasis patients from the Liberian rain-forest with low doses of diethylcarbamazine citrate after complete nodulectomy.
MedLine Citation:
PMID:  6420965     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
60 completely nodulectomized volunteers from the Liberian rain-forest were given an initial treatment with diethylcarbamazine citrate (DEC-C) for one week with gradually increasing doses up to a total of 1.1 g per patient. A long-term treatment followed with 50 mg DEC-C per week for 12 months. Immediately after the initial treatment the mean microfilarial density decreased to 4% to 6% of the pre-treatment level. After one year the microfilarial density had again increased to 12% to 29% of the pre-treatment level. Although the intake of the weekly 50 mg DEC-C was in no case regular, the microfilarial densities could be kept at a low level throughout the trial. However, even with the combined treatment--preceding nodulectomy and long-term trial with DEC-C--it was not possible to get the patients free from microfilariae.
Authors:
E J Albiez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Tropenmedizin und Parasitologie     Volume:  34     ISSN:  0303-4208     ISO Abbreviation:  Tropenmed Parasitol     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-14     Completed Date:  1984-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0423216     Medline TA:  Tropenmed Parasitol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  267-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Combined Modality Therapy
Diethylcarbamazine / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use
Drug Evaluation
Female
Follow-Up Studies
Humans
Male
Microfilaria / isolation & purification
Middle Aged
Onchocerca / isolation & purification
Onchocerciasis / drug therapy*,  parasitology,  surgery
Chemical
Reg. No./Substance:
90-89-1/Diethylcarbamazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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