| Long-term treatment of onchocerciasis patients from the Liberian rain-forest with low doses of diethylcarbamazine citrate after complete nodulectomy. | |
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MedLine Citation:
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PMID: 6420965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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60 completely nodulectomized volunteers from the Liberian rain-forest were given an initial treatment with diethylcarbamazine citrate (DEC-C) for one week with gradually increasing doses up to a total of 1.1 g per patient. A long-term treatment followed with 50 mg DEC-C per week for 12 months. Immediately after the initial treatment the mean microfilarial density decreased to 4% to 6% of the pre-treatment level. After one year the microfilarial density had again increased to 12% to 29% of the pre-treatment level. Although the intake of the weekly 50 mg DEC-C was in no case regular, the microfilarial densities could be kept at a low level throughout the trial. However, even with the combined treatment--preceding nodulectomy and long-term trial with DEC-C--it was not possible to get the patients free from microfilariae. |
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Authors:
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E J Albiez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tropenmedizin und Parasitologie Volume: 34 ISSN: 0303-4208 ISO Abbreviation: Tropenmed Parasitol Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-03-14 Completed Date: 1984-03-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0423216 Medline TA: Tropenmed Parasitol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 267-70 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Animals Combined Modality Therapy Diethylcarbamazine / administration & dosage, adverse effects, analogs & derivatives*, therapeutic use Drug Evaluation Female Follow-Up Studies Humans Male Microfilaria / isolation & purification Middle Aged Onchocerca / isolation & purification Onchocerciasis / drug therapy*, parasitology, surgery |
| Chemical | |
Reg. No./Substance:
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90-89-1/Diethylcarbamazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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