Document Detail

Long-term treatment of hypertension in the elderly with a combination of atenolol and nifedipine.
MedLine Citation:
PMID:  2188798     Owner:  NLM     Status:  MEDLINE    
The efficacy and tolerability of a once-daily, fixed combination of 50 mg atenolol and 20 mg nifedipine slow release were evaluated in a 12-month open study of 27 elderly hypertensives who were either newly presenting patients or were those who were inadequately controlled on previous monotherapy or had unacceptable side-effects with their current therapy. After 1-month's therapy with the combination, the mean sitting blood pressure 1 to 4 hours post-dose decreased from 176/103 mmHg to 146/83 mmHg and was maintained at this level for the remainder of the study. Eight patients complained of side-effects on study entry. Sixteen had complaints at some time during the 12 months of fixed combination treatment and 4 were withdrawn because of side-effects. Dizziness occurred in 6 patients on the combination but, as with side-effects overall, tended to resolve with time; its occurrence did not appear to correlate with the on-treatment blood pressure. In this group of elderly hypertension patients, therefore, the combination therapy with atenolol plus nifedipine slow release appeared to exert a greater antihypertensive effect compared with previous therapy, which included atenolol alone, with no evidence of tachyphylaxis and was reasonably well-tolerated over a 12-month period.
P J Fell
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Current medical research and opinion     Volume:  12     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  1990  
Date Detail:
Created Date:  1990-07-05     Completed Date:  1990-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  66-70     Citation Subset:  IM    
Health Centre, Deddington, England.
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MeSH Terms
Atenolol / administration & dosage,  adverse effects,  therapeutic use*
Clinical Trials as Topic
Delayed-Action Preparations
Dizziness / chemically induced
Drug Combinations
Hypertension / drug therapy*
Middle Aged
Nifedipine / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Drug Combinations; 21829-25-4/Nifedipine; 29122-68-7/Atenolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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