| Long-term treatment effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients. | |
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MedLine Citation:
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PMID: 12661776 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To assess the effect of atorvastatin on aortic stiffness in hypercholesterolaemic patients free of arterial hypertension and diabetes mellitus. METHODS AND RESULTS: The study included 36 patients (25 men and 11 women, mean age 56 +/- 12 years); 18 patients had stable coronary heart disease (CHD) and 18 were free of CHD at baseline. All patients received atorvastatin (20 mg/day) for a 2-year period. Aortic stiffness was assessed by transthoracic echocardiography at baseline and 2 years later. At baseline, total cholesterol, low density lipoprotein cholesterol (LDL-C) and LDL-C/high density lipoprotein cholesterol (HDL-C) ratio were positively related to aortic stiffness (p < 0.001 for all). The mean change in lipid parameters during treatment was: total cholesterol -38%, LDL-C -46%, triglycerides -29%, and HDL-C +6%, all significant (p = 0.029 to < 0.0001). After the 2-year treatment with atorvastatin, aortic stiffness was significantly reduced by 14% (p = 0.019). An improvement of left ventricular (LV) ejection fraction by 13% (p < 0.001) and a reduction of LV mass index by 9% (p = 0.008) were also recorded. The change in aortic stiffness was similar in patients with or without CHD. CONCLUSION: Long-term treatment with atorvastatin improves aortic stiffness; this index is related to total and coronary mortality. Moreover, assessment of aortic stiffness may be useful in identifying which hypercholesterolaemic patients should be treated aggressively, regardless of CHD. The aortic stiffness effect may eventually become an index of the efficacy of lipid lowering treatment. |
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Authors:
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Athanasios G Kontopoulos; Vasilios G Athyros; Anthimos N Pehlivanidis; Dimokritos S Demitriadis; Athanasios A Papageorgiou; Harisios Boudoulas |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Current medical research and opinion Volume: 19 ISSN: 0300-7995 ISO Abbreviation: Curr Med Res Opin Publication Date: 2003 |
Date Detail:
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Created Date: 2003-03-28 Completed Date: 2003-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: England |
Other Details:
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Languages: eng Pagination: 22-7 Citation Subset: IM |
Affiliation:
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Atherosclerosis Unit, Aristotelian University and Hippocration Hospital, Thessaloniki, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anticholesteremic Agents / administration & dosage, therapeutic use* Aortic Valve / physiopathology* Cardiovascular Diseases / diagnosis, physiopathology Echocardiography Female Heptanoic Acids / administration & dosage, therapeutic use* Humans Hypercholesterolemia / drug therapy*, physiopathology Male Middle Aged Placebos Pyrroles / administration & dosage, therapeutic use* Time United States |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Placebos; 0/Pyrroles; 110862-48-1/atorvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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