| Long-term treadmill exercise induces neuroprotective molecular changes in rat brain. | |
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MedLine Citation:
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PMID: 21817108 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Exercise enhances general health. However, its effects on neurodegeneration are controversial, and the molecular pathways in the brain involved in this enhancement are poorly understood. Here, we examined the effect of long-term moderate treadmill training on adult male rats cortex and hippocampus in order to identify the cellular mechanisms behind the effects of exercise. We compared three animal groups: exercised (30 min/d, 12m/min, 5d/w, 36w), handled but non-exercised (treadmill handling procedure, 0m/min), and sedentary (non-handled and non-exercise). Moderate long-term exercise induced an increase in IGF-1 levels and also in energy parameters, such as PGC-1α and the OXPHOS system. Moreover, the sirtuin 1 pathway was activated in both the exercised and non-exercised groups but not in sedentary rats, This induction could be a consequence of exercise as well as the handling procedure. To determine whether the long-term moderate treadmill training had neuroprotective effects, we studied tau hyperphosphorylation and GSK3β activation. Our results showed reduced levels of phosphotau and GSKβ activation mainly in the hippocampus of the exercised animals. In conclusion, in our rodent model, exercise improved several major brain parameters, especially in the hippocampus. These improvements induced the upregulation of sirtuin 1, a protein that extends life, the stimulation of mitochondrial biogenesis, the activation of AMPK, and the prevention of signs of neurodegeneration. These findings are consistent with other reports showing that physical exercise has positive effects on hormesis. |
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Authors:
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Sergi Bayod; Jaume Del Valle; Anna M Canudas; Jaume F Lalanza; Sandra Sanchez-Roigé; Antoni Camins; Rosa M Escorihuela; Merce Pallas |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-4 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1University of Barcelona. |
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