Document Detail


Long-term treadmill exercise-induced neuroplasticity and associated memory recovery of streptozotocin-induced diabetic rats: an experimenter blind, randomized controlled study.
MedLine Citation:
PMID:  19458438     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated a long-term exercise-induced neuroplasticity and spatial memory recovery in 15 rats in a treadmill as follows: normal control rats (NC), streptozotocin (STZ)-induced diabetic control rats (DC), and STZ-induced diabetic rats exercising in a treadmill (DE). As per the DE group, the running exercise in a treadmill was administered for 30 minutes a day for 6 weeks. Neuronal immediate-early gene (IEG) expression (c-Fos) in the hippocampus and radial arm maze (RAM) tests were measured and revealed that the c-Fos levels in DE were significantly higher than those in NC and DC (p < 0.05). Behavioral data analysis indicated that spatial memory performance scores, obtained from the RAM test, were significantly different among the three groups (p < 0.05). The memory scores of NC and DE were higher than those of DC (p < 0.05). These findings suggest that exercising in the treadmill increased neuronal immediate-early gene expression associated with neuroplasticity, thereby improving spatial memory. This is the first experimental evidence in literature that supports the efficacy of exercise-induced neuroplasticity and spatial motor memory in diabetes care.
Authors:
Joshua Sung H You; Chung-Ju Kim; Mee Young Kim; Yong Gwon Byun; So Young Ha; Bong Suk Han; Bum Chul Yoon
Related Documents :
20232078 - Effects of treadmill exercise training on liver fat accumulation and estrogen receptor ...
6144658 - Regulation of fatty acid biosynthesis in rats by physical training.
24476648 - Preventing obesity: exercise and daily activities of low-income pregnant women.
20655988 - Acute and chronic exercise modulates the expression of mor opioid receptors in the hipp...
2068908 - Reduced active protection to the cochlea during physical exercise.
6117378 - Demonstration of training effect during chronic beta-adrenergic blockade in patients wi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  NeuroRehabilitation     Volume:  24     ISSN:  1053-8135     ISO Abbreviation:  NeuroRehabilitation     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-08-20     Revised Date:  2009-12-29    
Medline Journal Info:
Nlm Unique ID:  9113791     Medline TA:  NeuroRehabilitation     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Affiliation:
Department of Physical Therapy, Graduate School of Rehabilitation Science, Yonsei University, Kangwon-do, Republic of Korea.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Diabetes Mellitus, Experimental / metabolism,  physiopathology,  psychology*
Hippocampus / metabolism
Male
Maze Learning / physiology
Memory Disorders / etiology,  metabolism,  therapy*
Neuronal Plasticity / physiology*
Physical Conditioning, Animal*
Proto-Oncogene Proteins c-fos / metabolism
Rats
Rats, Sprague-Dawley
Recovery of Function / physiology
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos
Comments/Corrections
Erratum In:
NeuroRehabilitation. 2009;24(4): 387

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of the corticospinal tract in motor recovery in patients with a stroke: A review.
Next Document:  Interaction of collagen triple-helix with carbon nanotubes: Geometric property of rod-like molecules...