Document Detail

Long-term treadmill exercise-induced neuroplasticity and associated memory recovery of streptozotocin-induced diabetic rats: an experimenter blind, randomized controlled study.
MedLine Citation:
PMID:  19458438     Owner:  NLM     Status:  MEDLINE    
We investigated a long-term exercise-induced neuroplasticity and spatial memory recovery in 15 rats in a treadmill as follows: normal control rats (NC), streptozotocin (STZ)-induced diabetic control rats (DC), and STZ-induced diabetic rats exercising in a treadmill (DE). As per the DE group, the running exercise in a treadmill was administered for 30 minutes a day for 6 weeks. Neuronal immediate-early gene (IEG) expression (c-Fos) in the hippocampus and radial arm maze (RAM) tests were measured and revealed that the c-Fos levels in DE were significantly higher than those in NC and DC (p < 0.05). Behavioral data analysis indicated that spatial memory performance scores, obtained from the RAM test, were significantly different among the three groups (p < 0.05). The memory scores of NC and DE were higher than those of DC (p < 0.05). These findings suggest that exercising in the treadmill increased neuronal immediate-early gene expression associated with neuroplasticity, thereby improving spatial memory. This is the first experimental evidence in literature that supports the efficacy of exercise-induced neuroplasticity and spatial motor memory in diabetes care.
Joshua Sung H You; Chung-Ju Kim; Mee Young Kim; Yong Gwon Byun; So Young Ha; Bong Suk Han; Bum Chul Yoon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  NeuroRehabilitation     Volume:  24     ISSN:  1053-8135     ISO Abbreviation:  NeuroRehabilitation     Publication Date:  2009  
Date Detail:
Created Date:  2009-05-21     Completed Date:  2009-08-20     Revised Date:  2009-12-29    
Medline Journal Info:
Nlm Unique ID:  9113791     Medline TA:  NeuroRehabilitation     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Department of Physical Therapy, Graduate School of Rehabilitation Science, Yonsei University, Kangwon-do, Republic of Korea.
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MeSH Terms
Diabetes Mellitus, Experimental / metabolism,  physiopathology,  psychology*
Hippocampus / metabolism
Maze Learning / physiology
Memory Disorders / etiology,  metabolism,  therapy*
Neuronal Plasticity / physiology*
Physical Conditioning, Animal*
Proto-Oncogene Proteins c-fos / metabolism
Rats, Sprague-Dawley
Recovery of Function / physiology
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos
Erratum In:
NeuroRehabilitation. 2009;24(4): 387

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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