| Long-term tracking of plasma phospholipid fatty acid concentrations and their correlation with the dietary intake of marine foods in newly diagnosed diabetic patients: results from a follow-up of the HUNT Study, Norway. | |
| | |
MedLine Citation:
|
PMID: 22846205 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Analysis of long-chain n-3 and n-6 fatty acid (FA) concentrations is used to evaluate their potential health effects in epidemiological studies, and, recently, also to counsel patients with a suboptimal intake of n-3 FA. Data on the method's ability to track and detect differences within and between individuals in appropriate populations are, however, lacking. The present study provides such data for twenty-nine plasma phospholipid (PL) FA concentrations and indices measured in 214 newly diagnosed type 2 diabetic patients at baseline and after 3 years. 20 : 3n-6 and the 20 : 4n-6:20 : 3n-6 ratio showed the highest tracking coefficients (Spearman's r 0·68), while DHA, EPA and PLN3-index (EPA+DHA) coefficients were 0·60, 0·47 and 0·55, respectively. Fish consumption measured simultaneously with EPA, DHA, sum n-3 and PLN3 index showed Spearman's correlation coefficients of 0·47, 0·44, 0·48 and 0·49, respectively, decreasing to 0·20, 0·19, 0·22 and 0·21 when measured 3 years apart. The within-subject CV of EPA, DHA and PLN3 index were 39·9, 14·3 and 18·0 %, respectively. The corresponding between-subject CV were 33·6, 16·5 and 18·7 %, while the reference change values were 112, 41 and 52 %. In conclusion, PL n-3 FA concentrations showed a significant long-term tracking and were positively correlated with marine food intake. Analytical precision, biological variability, reference change value and the index of individuality of EPA, DHA and PLN3 index are similar to commonly used clinical biomarkers, supporting their validity as dietary markers in clinical and epidemiological work. |
| | |
Authors:
|
Morten Lindberg; Kristian Midthjell; Kristian S Bjerve |
Related Documents
:
|
21806725 - Farmers are the most trusted part of the australian food chain: results from a national... 11678595 - Arsenic contamination of groundwater and prevalence of arsenical dermatosis in the heta... 22470195 - Alkylresorcinol metabolites in urine correlate with the intake of whole grains and cere... 3888535 - Acute and sublethal effects of organotin compounds on aquatic biota: an interpretative ... 10492485 - Application of ozone for enhancing the microbiological safety and quality of foods: a r... 2292065 - The current status of nutrition labelling in the united kingdom. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-7-30 |
Journal Detail:
|
Title: The British journal of nutrition Volume: - ISSN: 1475-2662 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
|
Created Date: 2012-7-31 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: - |
Other Details:
|
Languages: ENG Pagination: 1-12 Citation Subset: - |
Affiliation:
|
Department of Medical Biochemistry, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Changing paradigms with molecular imaging of neuroendocrine tumors.
Next Document: Foot-and-Mouth Disease Virus Serotype O Phylodynamics: Genetic Variability Associated with Epidemiol...