| Long-term tissue coverage of a biodegradable polylactide polymer-coated biolimus-eluting stent: Comparative sequential assessment with optical coherence tomography until complete resorption of the polymer. | |
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MedLine Citation:
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PMID: 22093210 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Biolimus-eluting stents (BESs) with a biodegradable polymer in abluminal coating achieve more complete coverage at 9 months compared with sirolimus-eluting stents (SESs) with a durable polymer, as assessed by optical coherence tomography (OCT). Whether this advantage persists or augments after complete resorption of the polymer (>12 months) is unknown. METHODS: The LEADERS trial compared the performance of BES with that of SES. Patients were randomly allocated to a sequential angiographic follow-up, including OCT in selected sites, at 9 and 24 months. Struts coverage was compared using Bayesian hierarchical models as the primary outcome for the OCT substudy. RESULTS: Fifty-six patients (26 BES, 30 SES) were enrolled in the OCT substudy. Twenty-one patients (10 BES, 11 SES) agreed to perform a second OCT follow-up at 24 months. Eleven lesions and 12 stents were analyzed sequentially in the BES group (2,455 struts at 9 months, 2,131 struts at 24 months) and 11 lesions and 18 stents in the SES group (3,421 struts at 9 months, 4,170 struts at 24 months). The previously reported advantage of BES over SES in terms of better strut coverage at 9 months was followed by improvement in coverage of the SES, resulting in identical coverage in both BES and SES at 24 months: 1.5% versus 1.8% uncovered struts, difference -0.2%, 95% credibility interval, -3.2% to 2.6%, P = .84. CONCLUSIONS: More complete strut coverage of BES as compared with SES at 9 months was followed by improvement of coverage in SES between 9 and 24 months and a similar long-term coverage in both stent types at 24 months. |
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Authors:
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Juan Luis Gutiérrez-Chico; Peter Jüni; Héctor M García-García; Evelyn Regar; Eveline Nüesch; Francesco Borgia; Willem J van der Giessen; Simon Davies; Robert Jan van Geuns; Gioel Gabrio Secco; Susanne Meis; Stephan Windecker; Patrick W Serruys; Carlo di Mario |
Publication Detail:
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Type: Journal Article Date: 2011-10-07 |
Journal Detail:
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Title: American heart journal Volume: 162 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 922-31 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
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Erasmus Medical Centre, Thoraxcentre, Rotterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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