Document Detail

Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates.
MedLine Citation:
PMID:  14504447     Owner:  NLM     Status:  MEDLINE    
Chronic lung disease in infants continues to be problematic. Tidal liquid ventilation (TLV) improves lung mechanics and provides effective gas exchange. We hypothesized that premature lambs could be supported safely with TLV and evaluated 9 preterm lambs (132 days gestation) on TLV up to 72 h. Results (mean +/- SEM): pH 7.36 +/- 0.003, PaCO2 44 +/- 0.34 mm Hg, PaO2 170 +/- 4.8 mm Hg, compliance=1.65 +/- 0.24 ml/cm H2O/kg, mean arterial blood pressure=53 +/- 0.08 mm Hg, heart rate=189 +/- 1.5 bpm. Blood perflubron levels were 6.0 +/- 0.24 microg/ml over 24 h. Tissue perflubron levels increased from 81 +/- 7.0 microg/g at 24 h to 108 +/- 15 microg/g at 72 h (p<0.05). There was a difference in perflubron concentrations as a function of tissue (p<0.001) that correlated to lipid levels (r2=0.93, p<0.01). These data demonstrate that TLV is both safe and effective up to 72 h in premature lambs.
Cynthia Cox; Robert L Stavis; Marla R Wolfson; Thomas H Shaffer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biology of the neonate     Volume:  84     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-23     Completed Date:  2004-04-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  232-42     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Neonatology, The Bryn Mawr Hospital, Bryn Mawr, PA, USA.
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MeSH Terms
Cardiovascular Physiological Phenomena
Fluorocarbons / blood,  pharmacokinetics,  therapeutic use*
Liquid Ventilation*
Lung / anatomy & histology
Osmolar Concentration
Pulmonary Gas Exchange
Time Factors
Tissue Distribution
Grant Support
BRSG 501-978-78/RS/DRS NIH HHS
Reg. No./Substance:
0/Fluorocarbons; 423-55-2/perflubron

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