| Long-term therapy with policosanol improves treadmill exercise-ECG testing performance of coronary heart disease patients. | |
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MedLine Citation:
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PMID: 9760006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the effects of long-term lipid-lowering therapy with policosanol on the clinical evolution, and exercise-ECG testing responses of 45 coronary heart disease (CHD) patients with myocardial ischemia, documented by exercise 201T1-myocardial perfusion scintigraphy, in an overall randomized, double-blind, placebo-controlled trial, made for different test endpoints. Fifteen patients were treated with 5 mg of policosanol twice daily; another 15 patients were administered the same drug dose plus 125 mg aspirin; and the other 15 patients received placebo plus equal aspirin dose. They were followed for 20 months, previous baseline observations, with treadmill exercise-ECG, besides serum lipid test. Beneficial changes on proportions among the 2 policosanol groups and the placebo group, showed an increment on functional capacity class, a decrement on rest and exercise angina, and a significant decrease in cardiac events, and in ischemic ST segment response, especially in the policosanol plus aspirin group (p = 0.05, X2(2df) = 5.8; p = 0.04, p = 0.02; Fisher). After treatment, sets of mean changes revealed an increase on maximum oxygen uptake, and a decline on double product simultaneously in both policosanol groups (p < or = 0.02, p < or = 0.002; Pillais, Hotellings' T2), while the placebo group was impaired. Aerobic functional capacity percent showed an increment in policosanol groups (p < or = 0.05, paired T). Lipid levels improved as other endpoints already reported. A supposed ergogenic effect of octacosanol, policosanol's main active compound, was not detected with this design. These results show that policosanol-treated CHD patients improved clinical evolution, and exercise-ECG responses, owing to the amelioration of myocardial ischemia, even more when administered with aspirin. |
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Authors:
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R Stüsser; J Batista; R Padrón; F Sosa; O Pereztol |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical pharmacology and therapeutics Volume: 36 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-12-11 Completed Date: 1998-12-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: GERMANY |
Other Details:
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Languages: eng Pagination: 469-73 Citation Subset: IM |
Affiliation:
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Clinical Research Center, Havana University, Playa, Cuba. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticholesteremic Agents
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therapeutic use* Aspirin / therapeutic use Coronary Disease / drug therapy* Double-Blind Method Drug Therapy, Combination Exercise Test* / drug effects Fatty Alcohols / therapeutic use* Humans Platelet Aggregation Inhibitors / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Fatty Alcohols; 0/Platelet Aggregation Inhibitors; 142583-61-7/policosanol; 50-78-2/Aspirin |
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