Document Detail


Long-term therapy with policosanol improves treadmill exercise-ECG testing performance of coronary heart disease patients.
MedLine Citation:
PMID:  9760006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study examined the effects of long-term lipid-lowering therapy with policosanol on the clinical evolution, and exercise-ECG testing responses of 45 coronary heart disease (CHD) patients with myocardial ischemia, documented by exercise 201T1-myocardial perfusion scintigraphy, in an overall randomized, double-blind, placebo-controlled trial, made for different test endpoints. Fifteen patients were treated with 5 mg of policosanol twice daily; another 15 patients were administered the same drug dose plus 125 mg aspirin; and the other 15 patients received placebo plus equal aspirin dose. They were followed for 20 months, previous baseline observations, with treadmill exercise-ECG, besides serum lipid test. Beneficial changes on proportions among the 2 policosanol groups and the placebo group, showed an increment on functional capacity class, a decrement on rest and exercise angina, and a significant decrease in cardiac events, and in ischemic ST segment response, especially in the policosanol plus aspirin group (p = 0.05, X2(2df) = 5.8; p = 0.04, p = 0.02; Fisher). After treatment, sets of mean changes revealed an increase on maximum oxygen uptake, and a decline on double product simultaneously in both policosanol groups (p < or = 0.02, p < or = 0.002; Pillais, Hotellings' T2), while the placebo group was impaired. Aerobic functional capacity percent showed an increment in policosanol groups (p < or = 0.05, paired T). Lipid levels improved as other endpoints already reported. A supposed ergogenic effect of octacosanol, policosanol's main active compound, was not detected with this design. These results show that policosanol-treated CHD patients improved clinical evolution, and exercise-ECG responses, owing to the amelioration of myocardial ischemia, even more when administered with aspirin.
Authors:
R Stüsser; J Batista; R Padrón; F Sosa; O Pereztol
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  36     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-12-11     Completed Date:  1998-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  469-73     Citation Subset:  IM    
Affiliation:
Clinical Research Center, Havana University, Playa, Cuba.
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MeSH Terms
Descriptor/Qualifier:
Anticholesteremic Agents / therapeutic use*
Aspirin / therapeutic use
Coronary Disease / drug therapy*
Double-Blind Method
Drug Therapy, Combination
Exercise Test* / drug effects
Fatty Alcohols / therapeutic use*
Humans
Platelet Aggregation Inhibitors / therapeutic use
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Fatty Alcohols; 0/Platelet Aggregation Inhibitors; 142583-61-7/policosanol; 50-78-2/Aspirin

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