Document Detail

Long-term sympathetic and hemodynamic responses to clonidine in patients with cirrhosis and ascites.
MedLine Citation:
PMID:  1551536     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to examine the short- and long-term effects of the alpha 2-agonist clonidine on sympathetic overactivity, systemic, splanchnic, and renal circulation changes, and abnormal renal sodium excretion in cirrhotic patients with ascites. Of 17 patients, 8 received clonidine and 9 a placebo. Measurements were taken before and after either a single dose of clonidine (150 micrograms) and placebo or a 1-week treatment with clonidine (150 micrograms/day) and placebo. Clonidine but not placebo induced significant short- and long-term decreases in plasma norepinephrine concentrations in the pulmonary artery and the right renal vein. Acute clonidine administration induced a significant reduction in cardiac output, heart rate, arterial pressure, and hepatic venous pressure gradient but had no effect on renal hemodynamics. Long-term clonidine administration induced a significant decrease in the hepatic venous pressure gradient from 20.1 +/- 1.9 to 17.6 +/- 2.0 mm Hg (mean +/- SEM) but had no significant effects on systemic or renal hemodynamics or renal excretion of sodium. It is concluded that long-term clonidine administration in cirrhotic patients induced a sustained decrease in sympathetic nervous activity and portal pressure. In contrast, clonidine had no prolonged effect on systemic hemodynamics. In addition, short- and long-term clonidine administration did not modify renal hemodynamics or induce a natriuretic response in patients with ascites.
D Roulot; R Moreau; C Gaudin; Y Bacq; A Braillon; A Hadengue; P Frohly; D Lebrec
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  102     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-04-27     Completed Date:  1992-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1309-18     Citation Subset:  AIM; IM    
Laboratoire d'Hémodynamique Splanchnique, Hôpital Beaujon, Clichy.
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MeSH Terms
Ascites / physiopathology*
Clonidine / pharmacology*
Hemodynamics / drug effects*
Liver Cirrhosis / physiopathology*
Middle Aged
Norepinephrine / blood
Renal Circulation / drug effects
Sympathetic Nervous System / drug effects*
Reg. No./Substance:
4205-90-7/Clonidine; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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