Document Detail

Long-term survival of skin allografts in mice treated with fractionated total lymphoid irradiation.
MedLine Citation:
PMID:  785599     Owner:  NLM     Status:  MEDLINE    
Treatment of recipient Balb/c mice with fractionated, high-dose total lymphoid irradiation, a procedure commonly used in the therapy of human malignant lymphomas, resulted in fivefold prolongation of the survival of C57BL/Ka skin allografts despite major histocompatibility differences between the strains (H-2d and H-2b, respectively). Infusion of 10(7) (C57BL/Ka x Balb/c)F1 bone marrow cells after total lymphoid irradiation further prolonged C57BL/Ka skin graft survival to more than 120 days. Total lymphoid irradiation may eventually prove useful in clinical organ transplantation.
S Slavin; S Strober; Z Fuks; H S Kaplan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  193     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1976 Sep 
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1252-4     Citation Subset:  IM    
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MeSH Terms
Graft Rejection / radiation effects*
Leukocyte Count
Lymphocytes / immunology
Lymphoid Tissue / radiation effects*
Mice, Inbred BALB C
Mice, Inbred C57BL
Radiation Effects*
Skin Transplantation
Time Factors
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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