Document Detail


Long-term survival of patients with Hodgkin's disease. Treatment with cyclophosphamide, vinblastine, procarbazine, and prednisone.
MedLine Citation:
PMID:  7235809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Thirty-eight patients with advanced Hodgkin's disease were treated with a combination of cyclophosphamide, vinblastine, procarbazine, and prednisone (CVPP); the minimum period of observation for surviving patients was five years. Twenty-eight patients (74%) achieved complete remission; in 17 (61%), remissions lasted at least five years. Twenty-five (66%) of the 38 patients survived more than five years from the initiation of CVPP. There were no differences in either rates or duration of response when evaluation was performed for multiple pretreatment clinical features. However, survival was adversely influenced by advanced age, nodular sclerosis histologic subtype, and pretreatment bone marrow involvement. Two patients died, in remission, of overwhelming viral infections, and acute nonlymphocytic leukemia developed in one patient. In another patient, aseptic necrosis of the heads of both femora developed. Our data suggest that treatment with CVPP may result in long-term disease-free survival for patients with advanced Hodgkin's disease.
Authors:
G E Gibbs; B A Peterson; B J Kennedy; G Vosika; C D Bloomfield
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Archives of internal medicine     Volume:  141     ISSN:  0003-9926     ISO Abbreviation:  Arch. Intern. Med.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-07-23     Completed Date:  1981-07-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372440     Medline TA:  Arch Intern Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  897-900     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Cyclophosphamide / therapeutic use*
Drug Therapy, Combination
Female
Follow-Up Studies
Hodgkin Disease / drug therapy*
Humans
Male
Prednisone / therapeutic use*
Procarbazine / therapeutic use*
Prognosis
Vinblastine / therapeutic use*
Grant Support
ID/Acronym/Agency:
CA 19527/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 671-16-9/Procarbazine; 865-21-4/Vinblastine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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