Document Detail

Long-term survival and neurological outcome of patients who received recombinant tissue plasminogen activator during out-of-hospital cardiac arrest.
MedLine Citation:
PMID:  15135188     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The long-term outcome in patients who received recombinant tissue plasminogen activator during cardiopulmonary resuscitation (CPR) in out-of-hospital cardiac arrest (OHCA) of non-traumatic aetiology was assessed. METHODS: The neurological outcome in survivors and their level of performance, subjective well-being and quality of life were evaluated. RESULTS: A follow-up study of 27 cardiac arrest survivors was conducted; four patients (15%) died during the first year, a total of seven patients (26%) within 5 years. Twenty-two patients (81%) were discharged from hospital without neurological deficit (cerebral performance category (CPC) score: 1), three patients scored CPC 2 and two patients CPC 3. Heart failure classification on discharge was, according to the New York Heart Association (NYHA) criteria 2.1 +/- 0.9. Fifteen patients (56%) managed to return to their previous level of activity. At the time of follow-up 18 patients (67%) were still alive, of whom 15 responded to a survey regarding life satisfaction. Thirteen patients (87%) judged their situation to be worth living and twelve (80%) considered their survival a second chance, while five (33%) feared they could suffer another cardiac arrest. Reactions from close relatives included fear/anxiety (n = 14; 78%), a sustained burden on family life (n = 12; 67%), and occasional depression (n = 7; 39%). CONCLUSIONS: Thrombolytic therapy during cardiopulmonary resuscitation may produce a favourable neurological outcome. The majority of long-term survivors reported a good subjective quality of life. In one-third of close family members some negative factors had a lasting impact on the quality of daily living.
Wolfgang Lederer; Christa Lichtenberger; Christoph Pechlaner; Johann Kinzl; Gunnar Kroesen; Michael Baubin
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Resuscitation     Volume:  61     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-09-09     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  123-9     Citation Subset:  IM    
Division of Disaster and Emergency Medicine, Department of Anaesthesia and Critical Care Medicine, The Leopold Franzens University of Innsbruck, Anichstrasse 35, A-6020 Innsbruck, Austria.
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MeSH Terms
Cardiopulmonary Resuscitation / adverse effects,  methods*
Cohort Studies
Combined Modality Therapy
Disability Evaluation
Emergency Medical Services
Follow-Up Studies
Heart Arrest / mortality*,  therapy
Middle Aged
Nervous System Diseases / epidemiology*,  etiology
Proportional Hazards Models
Quality of Life*
Retrospective Studies
Survival Analysis
Time Factors
Tissue Plasminogen Activator / therapeutic use*
Treatment Outcome
Reg. No./Substance:
EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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