| Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function. | |
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MedLine Citation:
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PMID: 12727154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The purpose of this study was to evaluate the influence of left ventricular systolic function on the survival in a large consecutive cohort of patients hospitalized with congestive heart failure and to determine how left ventricular systolic function interacts with co-morbid conditions in terms of prognosis. METHODS AND RESULTS: Analysis of survival data from 5491 patients admitted for new or worsening heart failure to 34 departments of cardiology or internal medicine in Denmark from 1993-1996 was carried out. A standardized echocardiogram was available for 95% of the patients, and left ventricular systolic function was estimated using wall motion index score. Follow-up time was 5-8 years. Patients with preserved systolic function were older, more frequently female, and had less evidence of ischemia than patients with systolic dysfunction. After 1 year, 24% of the patients had died. Low wall motion index was a potent independent predictor of death (risk ratio for one unit increase, 0.60 (0.56-0.64)), and was of greater prognostic significance in younger patients and patients with a history of myocardial ischemia. However, even in patients with preserved systolic function, mortality was high (1 year mortality, 19%). CONCLUSION: In hospitalized heart failure patients, particularly in younger patients with ischemic heart disease, mortality risk is inversely related to left ventricular systolic function. |
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Authors:
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Finn Gustafsson; Christian Torp-Pedersen; Bente Brendorp; Marie Seibaek; Hans Burchardt; Lars Køber; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European heart journal Volume: 24 ISSN: 0195-668X ISO Abbreviation: Eur. Heart J. Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-05-02 Completed Date: 2003-06-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006263 Medline TA: Eur Heart J Country: England |
Other Details:
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Languages: eng Pagination: 863-70 Citation Subset: IM |
Affiliation:
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Department of Cardiology and Endocrinology E, Frederiksberg University Hospital, Frederiksberg, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cohort Studies Confidence Intervals Female Heart Failure / mortality*, therapy Hospital Mortality Hospitalization* Humans Male Prognosis Survival Analysis Ventricular Dysfunction, Left / complications, mortality* |
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