| Long-term survival from respiratory failure after marrow transplantation for malignancy. | |
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MedLine Citation:
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PMID: 1546828 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Respiratory failure was measured as the institution of assisted mechanical ventilation for hypoxemic (oxygenation) or hypercarbic (ventilatory) failure after marrow transplantation. There were 348 (23%) marrow recipients who required mechanical ventilation for an average of 8 days (median, 5; range, 1 to 45). The average onset of mechanical ventilation was 39 days (median, 22; range, 0 to 172) after transplantation. Factors previously found to be associated with mechanical ventilation were tested in a Cox proportional hazards model. Older age, active malignancy at time of transplantation, and donor-recipient marrow HLA-non-identity were independent risks for assisted mechanical ventilation after marrow transplantation. Twenty-one percent (n = 72) of the marrow recipients receiving assisted mechanical ventilation for respiratory failure were extubated. Four percent (n = 15) were discharged from the hospital, and 3% (n = 10) survived 6 months after transplantation. All of these survivors were physically functional. Three had mild chronic respiratory symptoms and restrictive or obstructive airflow defects 1 yr after transplantation. Respiratory failure requiring assisted mechanical ventilatory support occurs in 23% of marrow recipients and is associated with functional survival at 6 months in 3%. Older age, active malignancy at time of transplantation, and donor-recipient marrow HLA-non-identity are risk factors for subsequent respiratory failure. In view of the poor prognosis associated with respiratory failure, these factors should be considered when counseling patients and families regarding this mode of treatment. |
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Authors:
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S W Crawford; F B Petersen |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American review of respiratory disease Volume: 145 ISSN: 0003-0805 ISO Abbreviation: Am. Rev. Respir. Dis. Publication Date: 1992 Mar |
Date Detail:
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Created Date: 1992-04-10 Completed Date: 1992-04-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370523 Medline TA: Am Rev Respir Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 510-4 Citation Subset: AIM; IM |
Affiliation:
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Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98104. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Bone Marrow Transplantation / mortality*, statistics & numerical data Child Child, Preschool Humans Infant Middle Aged Neoplasms / mortality, therapy* Proportional Hazards Models Respiration, Artificial / statistics & numerical data Respiratory Function Tests Respiratory Insufficiency / etiology, mortality*, therapy Risk Factors Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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CA-18029/CA/NCI NIH HHS; CA-47748/CA/NCI NIH HHS; HL-36444/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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