| Long-term suppressive therapy for pulmonary aspergilloma in an immunocompromised man with AIDS. Is it always necessary? | |
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MedLine Citation:
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PMID: 19451335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aspergillus infections are rare opportunistic infections in the course of AIDS and they mostly present as invasive pulmonary disease. Owing to the prolonged survival of profoundly immunocompromised patients with AIDS, invasive pulmonary aspergillosis is being reported with increased frequency. However, although pulmonary aspergilloma has been well described in immunocompetent patients, it has been rarely reported in AIDS patients. The treatment for pulmonary aspergilloma remains challenging and often needs lifelong treatment to minimize fatal haemoptysis, which can occur in up to 25%, and progression to secondary invasive aspergillosis. We report a case of pulmonary aspergilloma in a severely immunocompromised patient with AIDS who stopped taking systemic antifungal treatment in April 1998 and remained well with little progression of invasive aspergillosis up until March 2002 when he died of acute pancreatitis related to a drug interaction of didanosine and tenofovir. |
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Authors:
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K Yoganathan |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of STD & AIDS Volume: 20 ISSN: 0956-4624 ISO Abbreviation: Int J STD AIDS Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-19 Completed Date: 2009-08-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007917 Medline TA: Int J STD AIDS Country: England |
Other Details:
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Languages: eng Pagination: 434-6 Citation Subset: IM; X |
Affiliation:
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Singleton Hospital, Sketty, Swansea SA2 8QA, Wales, UK. kathir.yoganathan@swansea-tr.wales.nhs.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy*,
microbiology Adenine / adverse effects, analogs & derivatives Anti-HIV Agents / adverse effects Antifungal Agents* / administration & dosage, therapeutic use Aspergillosis / drug therapy*, microbiology, radiography Didanosine / adverse effects Drug Administration Schedule Drug Interactions Fatal Outcome HIV Infections / complications* Humans Immunocompromised Host* Lung Diseases, Fungal / drug therapy*, radiography Male Middle Aged Pancreatitis / etiology Phosphonic Acids / adverse effects Reverse Transcriptase Inhibitors / adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Antifungal Agents; 0/Phosphonic Acids; 0/Reverse Transcriptase Inhibitors; 107021-12-5/tenofovir; 69655-05-6/Didanosine; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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