Document Detail


Long-term suppressive combined antiretroviral treatment does not normalize the serum level of soluble CD14.
MedLine Citation:
PMID:  23322858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of soluble CD14 (sCD14) were longitudinally measured in 85 human immunodeficiency virus (HIV)-infected subjects during long-term receipt of suppressive combined antiretroviral therapy (cART) and compared to those in young and elderly HIV-negative control subjects. cART did not normalize sCD14 levels; rather, the HIV-infected group displayed a significantly higher sCD14 level at baseline (ie, before cART initiation), 1 year after cART initiation, and 5 years after cART initiation, compared with both control groups. Furthermore, the baseline CD4(+) T-cell count was inversely associated with the baseline sCD14 level. Our results point to the necessity of complementary therapies to treat the activated/inflamed status associated with chronic HIV infection and to the benefits of early initiation of cART.
Authors:
Gema Méndez-Lagares; M Concepción Romero-Sánchez; Ezequiel Ruiz-Mateos; Miguel Genebat; Sara Ferrando-Martínez; María Á Muñoz-Fernández; Yolanda M Pacheco; Manuel Leal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-15
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  207     ISSN:  1537-6613     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-21     Completed Date:  2013-05-06     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1221-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Retroviral Agents / pharmacology,  therapeutic use*
Antigens, CD14 / blood*
CD4 Lymphocyte Count
Case-Control Studies
Cyclohexanes / pharmacology,  therapeutic use*
Female
HIV Infections / blood,  drug therapy*,  immunology
HIV-1 / pathogenicity
Humans
Longitudinal Studies
Male
Middle Aged
RNA, Viral / blood
Solubility
Time Factors
Treatment Outcome
Triazoles / pharmacology,  therapeutic use*
Viral Load
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/Antigens, CD14; 0/Cyclohexanes; 0/RNA, Viral; 0/Triazoles; MD6P741W8A/maraviroc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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