| Long-term suppressive combined antiretroviral treatment does not normalize serum sCD14 levels. | |
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MedLine Citation:
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PMID: 23322858 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Soluble CD14 (sCD14) levels were longitudinally analyzed in eighty-five HIV-infected subjects after a long-term suppressive cART and compared to young and elderly control HIV-negative groups. cART did not normalize sCD14 levels; in fact, HIV-infected subjects displayed significantly higher sCD14 levels at baseline pre-cART, 1-year and 5-years cART compared to both controls. Furthermore, baseline pre-cART CD4 T-cell counts were inversely associated with baseline pre-cART sCD14 levels.Our results point to the necessity of complementary therapies to treat the activated/inflamed status associated with chronic HIV-infection and to the benefit of an early initiation of cART. |
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Authors:
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Gema Méndez-Lagares; M Concepción Romero-Sánchez; Ezequiel Ruiz-Mateos; Miguel Genebat; Sara Ferrando-Martínez; María Ángeles Muñoz-Fernández; Yolanda María Pacheco; Manuel Leal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-15 |
Journal Detail:
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Title: The Journal of infectious diseases Volume: - ISSN: 1537-6613 ISO Abbreviation: J. Infect. Dis. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Immunovirology, Biomedicine Institute of Seville, Service of Infectious Diseases; Virgen del Rocío University Hospital, (IBiS/CSIC/SAS/University of Seville), Seville Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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