Document Detail

Long-term supplementation with selenate and selenomethionine: selenium and glutathione peroxidase (EC in blood components of New Zealand women.
MedLine Citation:
PMID:  8490010     Owner:  NLM     Status:  MEDLINE    
Thirty-three New Zealand women aged 18-23 years received daily for 32 weeks, 200 micrograms Se as Se-enriched yeast (selenomethionine), or brewer's yeast mixed with selenate, or no added Se (placebo) in a double-blind trial. Se supplementation raised (P = 0.001) platelet glutathione peroxidase (EC; GSHPx) activity, and also Se and GSHPx in whole blood, erythrocytes and plasma. Selenomethionine was more effective in raising blood Se concentrations than selenate, but both were equally effective in raising GSHPx activities in whole blood, erythrocytes and plasma, indicating a similar bioavailability for the two forms. These observations and those of gel filtration studies of erythrocytes and plasma proteins reported elsewhere (Butler et al. 1991) are consistent with the incorporation of Se from selenomethionine into a general tissue protein pool while selenate is directly available for GSHPx synthesis, and explain the poorer correlation between Se and GSHPx in individuals with higher Se status. However, selenate raised platelet GSHPx activities to a greater extent than did selenomethionine suggesting some other effect of selenate on platelets which needs further investigation. A response of GSHPx activity in these New Zealand subjects indicates that their dietary Se intake is insufficient to meet recommended intakes based on the criterion of saturation of GSHPx activity, and could reflect a marginal Se status. The level of blood Se necessary for saturation of GSHPx of about 100 ng Se/ml whole blood confirms observations in earlier studies.
C D Thomson; M F Robinson; J A Butler; P D Whanger
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The British journal of nutrition     Volume:  69     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-06-15     Completed Date:  1993-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  577-88     Citation Subset:  IM    
Department of Human Nutrition, University of Otago, Dunedin, New Zealand.
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MeSH Terms
Biological Availability
Blood Platelets / enzymology
Double-Blind Method
Erythrocytes / enzymology
Glutathione Peroxidase / blood*
New Zealand
Plasma / enzymology
Selenium / administration & dosage,  blood*,  pharmacokinetics*
Selenium Compounds*
Selenomethionine / administration & dosage,  pharmacokinetics*
Time Factors
Reg. No./Substance:
0/Selenium Compounds; 1464-42-2/Selenomethionine; 7782-49-2/Selenium; 7783-08-6/selenic acid; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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