Document Detail

Long-term supplementation with n-3 fatty acids, II: Effect on neutrophil and monocyte chemotaxis.
MedLine Citation:
PMID:  1411255     Owner:  NLM     Status:  MEDLINE    
The effect of a daily supplement with 4 g of n-3 polyunsaturated fatty acids (PUFA) for 9 months to 24 healthy volunteers on neutrophil and monocyte chemotaxis was studied using the under-agarose technique. Autologous serum and n-formyl-methionyl-leucyl-phenylalanine were used as chemoattractants. The effect after 9 months of supplementation with n-3 PUFA was also compared to results after short-term supplementation with n-3 PUFA for 6 weeks. Monocyte chemotaxis was reduced after 9 months of supplementation with n-3 PUFA to the same extent as after 6 weeks supplement. Neutrophil-directed migration towards chemoattractants was reduced after 9 months on fish oil, and this decrease was significantly greater than the decrease obtained after 6 weeks of supplementation. The spontaneous migration of neutrophils was significantly attenuated after 9 months compared to baseline and to 6 weeks. These findings lend support to a role for n-3 PUFA in the management of chronic inflammatory and atherosclerotic vascular diseases.
E B Schmidt; K Varming; J O Pedersen; H H Lervang; N Grunnet; C Jersild; J Dyerberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  52     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-11-23     Completed Date:  1992-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
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MeSH Terms
Cell Movement / physiology
Cell Separation
Chemotaxis, Leukocyte / physiology*
Dietary Fats / administration & dosage*
Fatty Acids, Omega-3
Fatty Acids, Unsaturated / administration & dosage*
Fish Oils / administration & dosage
Middle Aged
Monocytes / physiology
Neutrophils / physiology
Reference Values
Reproducibility of Results
Time Factors
Triglycerides / administration & dosage
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 0/Fish Oils; 0/Triglycerides; 100085-40-3/Pikasol

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