Document Detail


Long-term study of normal kidneys transplanted into patients with type I diabetes.
MedLine Citation:
PMID:  2647558     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the rate of development of the lesions of diabetic nephropathy in transplanted kidneys residing for 6-14 yr in type I (insulin-dependent) diabetic kidney-allograft recipients. Although each recipient had end-stage diabetic nephropathy with his/her own kidneys, there was marked variability in the rate of development of mesangial expansion observed in the transplanted kidneys. The progression of glomerular pathology, including widening of the glomerular basement membrane and expansion of the mesangium, did not correlate significantly with several potential risk factors (e.g., donor source--cadaver or living related, histocompatibility match, age of the recipient or donor, age at onset of diabetes, duration of diabetes before renal failure, immunosuppressive drug dose, blood pressure, and severity of lesions of chronic rejection). However, there was a direct albeit imprecise relationship between the index of mesangial expansion at the final biopsy and the index of glycemic control (r = .61, P less than .01). These observations suggest that currently unknown factor(s) may modulate the progression of diabetic renal disease, even in a population that had uniformly demonstrated nephropathy risk. Our data support the hypothesis that in addition to glycemic control per se, there are risk factors intrinsic to the kidney itself.
Authors:
S M Mauer; F C Goetz; L E McHugh; D E Sutherland; J Barbosa; J S Najarian; M W Steffes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diabetes     Volume:  38     ISSN:  0012-1797     ISO Abbreviation:  Diabetes     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-05-04     Completed Date:  1989-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372763     Medline TA:  Diabetes     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  516-23     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Blood Glucose / analysis
Blood Pressure
Child
Creatinine / metabolism
Diabetes Mellitus, Type 1 / pathology,  physiopathology,  surgery*
Diabetic Nephropathies / pathology,  physiopathology,  surgery*
Female
Humans
Kidney / pathology
Kidney Transplantation*
Longitudinal Studies
Male
Proteinuria
Grant Support
ID/Acronym/Agency:
AI-10704/AI/NIAID NIH HHS; AM-13083/AM/NIADDK NIH HHS; AM-20742/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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