Document Detail

Long-term and strict blood pressure lowering by imidapril reverses left ventricular hypertrophy in patients with essential hypertension: an evaluation using a novel indicator of burden on the left ventricle.
MedLine Citation:
PMID:  16755142     Owner:  NLM     Status:  MEDLINE    
Left ventricular hypertrophy is an independent risk factor for cardiovascular disease. We evaluated the effect of long-term and strict antihypertensive therapy with and without the angiotensin-converting enzyme inhibitor (ACEI) imidapril on left ventricular hypertrophy using a novel indicator of chronic burden on the left ventricle, the area under the blood pressure curve x the duration of high blood pressure (AUSBP and AUDBP), in patients with essential hypertension. The patients were divided into 2 groups: an ACEI group, in which imidapril was used in addition to antihypertensive drugs such as Ca channel blockers, beta-blockers, diuretics or angiotensin II antagonist; and a non-ACEI group, in which Ca channel blockers and diuretics were used. Systolic and diastolic blood pressures (SBP and DBP) were both maintained at below 140 and 90 mmHg, respectively, for 2 years. There was no significant difference in the left ventricular mass (LVM) assessed by echocardiography at baseline and that at 2 years of follow-up in the non-ACEI group. However, the LVM in the ACEI group was significantly decreased at 2 years of follow-up as compared to that at the baseline visit. There was no difference in the mean AUSBP and AUDBP between the ACEI and non-ACEI groups. Changes in the LVM were not correlated with the AUSBP or AUDBP in both the ACEI and non-ACEI groups. These findings suggest that the decrease in the LVM in the ACEI group was mediated through mechanisms other than the blood pressure lowering-effect and that AUSBP and AUDBP may be novel indicators of the long-term burden on the left ventricle.
Masahiko Takahashi; Shinya Minatoguchi; Kazuhiko Nishigaki; Masanori Kawasaki; Masazumi Arai; Yoshihiro Uno; Hisayoshi Fujiwara
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  29     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-06-09     Completed Date:  2006-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  89-94     Citation Subset:  IM    
Second Department of Internal Medicine, Gifu University School of Medicine, Yanagido 1-1, Gifu 501-1911, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / therapeutic use*
Blood Pressure / physiology
Heart Ventricles / physiopathology
Hypertension / drug therapy*,  physiopathology
Hypertrophy, Left Ventricular / drug therapy*
Imidazolidines / therapeutic use*
Middle Aged
Prospective Studies
Time Factors
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Imidazolidines; 89396-94-1/imidapril

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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