Document Detail

Long-term stable periodontal regeneration by means of autologous bone grafting in patients with severe periodontitis.
MedLine Citation:
PMID:  22292144     Owner:  NLM     Status:  MEDLINE    
Periodontal regeneration in patients with advanced periodontitis and severe attachment loss has classically presented some of the greatest challenges to the practitioner. The purpose of this article is to describe the staged treatment approach and long-term follow-up of a case with generalized advanced chronic periodontitis. Microbial sampling for suspected periodontopathogens was done before and after treatment. Autogenous bone grafting was used to repair bilateral mandibular vertical defects on both molars and premolars. Reentry surgery at 6 months demonstrated 100% defect fill. Clinical, radiographic, and microbiologic evidence at 8 years suggested a stable outcome. Qualitative polymerase chain reaction (PCR) analysis was done to detect the presence of cytomegalovirus, Epstein-Barr virus type 1, and common periodontopathogens 8 years after active periodontal therapy. Negative PCR results 8 years after treatment confirmed that pathogenic subgingival reservoirs were successfully eradicated.
Fernando Verdugo; Antonio D'Addona
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The International journal of periodontics & restorative dentistry     Volume:  32     ISSN:  1945-3388     ISO Abbreviation:  Int J Periodontics Restorative Dent     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-01-31     Completed Date:  2012-07-20     Revised Date:  2013-04-30    
Medline Journal Info:
Nlm Unique ID:  8200894     Medline TA:  Int J Periodontics Restorative Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  D    
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MeSH Terms
Aggressive Periodontitis / microbiology,  surgery*,  virology
Alveolar Bone Loss / surgery
Bicuspid / surgery
Bone Transplantation / methods*
Chronic Periodontitis / microbiology,  surgery*,  virology
Cytomegalovirus / isolation & purification
Follow-Up Studies
Gram-Negative Bacteria / isolation & purification
Herpesvirus 4, Human / isolation & purification
Longitudinal Studies
Middle Aged
Molar / surgery
Periodontal Attachment Loss / surgery
Periodontal Pocket / surgery
Regeneration / physiology
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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