Document Detail

Long-term stabilization of leptomeningeal disease with whole-brain radiation therapy in a patient with metastatic melanoma treated with vemurafenib: a case report.
MedLine Citation:
PMID:  23358426     Owner:  NLM     Status:  MEDLINE    
We present a patient with metastatic BRAF-mutated melanoma who achieved long-term stabilization of leptomeningeal disease (LMD) with sequential whole-brain radiation therapy and vemurafenib. A 53-year-old woman with melanoma that harbored the BRAF V600E mutation and had that metastasized to multiple lymph nodes, lungs, breast, and subcutaneous tissue had developed symptomatic LMD 16 months after starting vemurafenib treatment despite achieving a substantial response at the existing metastatic sites. Vemurafenib was discontinued for 7 days, she received whole-brain radiation therapy (30 Gy in 10 fractions), and 7 days after completing the radiation therapy, she resumed vemurafenib therapy. The neurologic symptoms improved significantly, and a cerebrospinal fluid examination revealed disappearance of melanoma cells. She remained alive with radiologically stable LMD for at least 18 months after the whole-brain radiation therapy.
Jee Min Lee; Urvi N Mehta; Ly H Dsouza; Beverly Ashleigh Guadagnolo; Deborah L Sanders; Kevin B Kim
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Melanoma research     Volume:  23     ISSN:  1473-5636     ISO Abbreviation:  Melanoma Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-02-28     Completed Date:  2014-01-22     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  9109623     Medline TA:  Melanoma Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  175-8     Citation Subset:  IM    
Copyright Information:
© 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.
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MeSH Terms
Brain Neoplasms / radiotherapy*,  secondary
Indoles / therapeutic use*
Melanoma / drug therapy*,  pathology,  radiotherapy*
Meningeal Neoplasms / radiotherapy*,  secondary
Middle Aged
Skin Neoplasms / drug therapy*,  pathology,  radiotherapy*
Sulfonamides / therapeutic use*
Grant Support
Reg. No./Substance:
0/Indoles; 0/PLX4032; 0/Sulfonamides

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