Document Detail

Long-term stability study of histamine in sterile bronchoprovocation solutions.
MedLine Citation:
PMID:  3953600     Owner:  NLM     Status:  MEDLINE    
The long-term stability of histamine in sterile bronchoprovocation solutions stored under different conditions was studied. Histamine solutions (2 and 8 mg/mL) were stored in specially adapted translucent and black plastic bottles and kept in a cool place (12 degrees C) and exposed to fluorescent light (500 foot-candles intensity). Multiple aliquots of each concentration were also stored at -20 degrees C in 12 X 75 mm sterile polypropylene tubes with snap caps and covered with aluminum foil. The content of histamine in the stored samples was determined by a stability-indicating colorimetric assay. The histamine solutions were stable for up to eight months at 12 degrees C when stored in either of the specially adapted translucent or black plastic bottles, irrespective of normal long-term exposure to fluorescent light. No important changes were observed in the histamine concentration when these solutions were stored at -20 degrees C in polypropylene tubes for up to a year. Histamine solutions used in bronchoprovocation tests can be stored in plastic bottles in a cool place or in the refrigerator. It is not necessary to protect these solutions from normal long-term exposures to fluorescent light to ensure clinically acceptable stability.
R K Marwaha; B F Johnson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hospital pharmacy     Volume:  43     ISSN:  0002-9289     ISO Abbreviation:  Am J Hosp Pharm     Publication Date:  1986 Feb 
Date Detail:
Created Date:  1986-04-24     Completed Date:  1986-04-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370474     Medline TA:  Am J Hosp Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  380-3     Citation Subset:  IM    
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MeSH Terms
Bronchial Provocation Tests*
Drug Packaging
Drug Stability
Drug Storage
Histamine / analysis,  diagnostic use*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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