| Long-term stability of dentin matrix following treatment with various natural collagen cross-linkers. | |
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MedLine Citation:
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PMID: 21783144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Collagen disorganization is one of the main degradation patterns found in unsuccessful adhesive restorations. The hypothesis of this study was that pretreatment using natural collagen cross-linking agents rich in proanthocyanidin (PA) would improve mechanical properties and stability over time of the dentin collagen and, thus, confer a more resistant and lasting substrate for adhesive restorations. METHODS: PA-based extracts, from grape seed (GSE), cocoa seed (CSE), cranberry (CRE), cinnamon (CNE) and açaí berry (ACE) were applied over the demineralized dentin. The apparent elastic modulus (E) of the treated dentin collagen was analyzed over a 12 month period. Specimens were immersed in the respective solution and E values were obtained by a micro-flexural test at baseline, 10, 30, 60, 120 and 240 min. Samples were stored in artificial saliva and re-tested after 3, 6 and 12 months. Data was analyzed using ANOVA and Tukey test. RESULTS: GSE and CSE extracts showed a time-dependent effect and were able to improve [240 min (MPa): GSE = 108.96 ± 56.08;CSE = 59.21 ± 24.87] and stabilize the E of the organic matrix [12 months (MPa): GSE = 40.91 ± 19.69;CSE = 42.11 ± 13.46]. CRE and CNE extracts were able to maintain the E of collagen matrices constant over 12 months [CRE = 11.17 ± 7.22;CNE = 9,96 ± 6.11;MPa]. ACE (2.64 ± 1.22 MPa) and control groups immersed in neat distilled water (1.37 ± 0.69 MPa) and ethanol-water (0.95 ± 0.33 MPa) showed no effect over dentin organic matrix and enable their degradation and reduction of mechanical properties. SIGNIFICANCE: Some PA-based extracts were capable of improving and stabilizing collagen matrices through exogenous cross-links induction. |
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Authors:
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Carina Strano Castellan; Ana Karina Bedran-Russo; Sachin Karol; Patrícia Nóbrega Rodrigues Pereira |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-08 |
Journal Detail:
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Title: Journal of the mechanical behavior of biomedical materials Volume: 4 ISSN: 1878-0180 ISO Abbreviation: J Mech Behav Biomed Mater Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-07-25 Completed Date: 2011-11-25 Revised Date: 2013-02-08 |
Medline Journal Info:
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Nlm Unique ID: 101322406 Medline TA: J Mech Behav Biomed Mater Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1343-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Dental Materials, University of Sao Paulo, Av. Professor Lineu Prestes 2227, 0508-000 Sao Paulo, Brazil. carina@usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Agents
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chemistry* Biomimetics Collagen / chemistry*, metabolism Cross-Linking Reagents / chemistry* Dental Cements / chemistry, metabolism Dental Restoration, Permanent Dentin / chemistry*, metabolism Elastic Modulus Plant Extracts / chemistry Proanthocyanidins / chemistry Saliva / metabolism Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DE017740/DE/NIDCR NIH HHS; K08 DE017740-04/DE/NIDCR NIH HHS; K08 DE017740-04S1/DE/NIDCR NIH HHS; K08 DE017740-05/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Agents; 0/Cross-Linking Reagents; 0/Dental Cements; 0/Plant Extracts; 0/Proanthocyanidins; 18206-61-6/proanthocyanidin; 9007-34-5/Collagen |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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