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Long-term serial angiographic outcomes after sirolimus-eluting stent implantation.
MedLine Citation:
PMID:  22517538     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: We evaluated, using quantitative coronary angiography, the natural history of change that occurred in target lesions after successful sirolimus-eluting stent (SES) implantation. BACKGROUND: Percutaneous coronary intervention (PCI) with drug-eluting stents (DES) has significantly reduced the rate of repeated target lesion revascularization (TLR). However, early studies have raised concerns regarding the 'late catch-up' phenomenon of DES. METHODS: Between June 2004 and March 2007, consecutive 217 patients with 306 lesions without restenosis at early angiographic follow-up underwent late angiographic follow-up (early follow-up: 11.2 ± 2.1 months and late follow-up: 29.4 ± 5.2 months). Predictors of late catch-up were identified with univariate and multivariate regression analyses. RESULTS: Although reference vessel diameter did not significantly change during follow-up (3.15 mm (interquartile range (IQR): 2.81-3.49 mm), 3.12 mm (IQR: 2.79-3.47 mm) and 3.08 mm (IQR: 2.76-3.46 mm) at post-procedure, and early and late angiographic follow-up, respectively; p = 0.2653), late loss (LL) significantly increased during follow-up (0.05 mm (IQR: 0.00-0.13 mm) and 0.08 mm (IQR: 0.01-0.19mm) at early and late follow up, respectively; p < 0.0001). Univariate analysis showed previous intervention, adjunctive use of cutting balloon, lesion length and progression of MLD, LL, %DS at early follow-up as predictors of late catch-up. Multivariate regression analysis identified %DS at early follow-up as a predictor of late catch-up (OR 1.076, CI 1.039 - 1.114, p < 0.0001). CONCLUSION: Significant and continuous progression of neointima after SES implantation was observed in the present study. Larger late loss may be a sign of late catch-up phenomenon. © 2012 Wiley Periodicals, Inc.
Authors:
Euihong Ko; Kenya Nasu; Maoto Habara; Nobuyoshi Tanaka; Masashi Kimura; Yoshihisa Kinoshita; Etsuo Tsuchikane; Yasushi Asakura; Osamu Katoh; Takahiko Suzuki
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-19
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
The department of Cardiology, Toyohashi Heart Center. Japan yoshi@kuhp.kyoto-u.ac.jp.
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