| Long-term safety and tolerability of flutamide for the treatment of hirsutism. | |
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MedLine Citation:
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PMID: 18339379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the long-term safety and tolerability of flutamide therapy for hirsutism. DESIGN: Prospective observational study. SETTING: Gynecology department in a teaching hospital. PATIENT(S): Hyperandrogenic women presenting for hirsutism treatment were followed between January 2000 and January 2007. INTERVENTION(S): Women received flutamide 250 mg/day alone (n = 27) or combined with a fixed dose of an oral contraceptive containing 0.020 mg of ethinyl estradiol (EE) and 0.15 mg of desogestrel (n = 56). MAIN OUTCOME MEASURE(S): Adverse events, safety, tolerability and efficacy were assessed every 6 months during the follow-up. Liver and lipid profiles were also recorded. RESULT(S): Patients under flutamide therapy showed, compared with basal values, a significant progressive decrease in hirsutism scores after 6 months of treatment with a maximum effect at 12 months that was maintained during the 84 months of follow-up. A total of 40.96% women presented one or more adverse effects during the follow-up; 33.73% showed at least one adverse effect possibly related with the study drug, and 24.09% withdrew from the study because of adverse effects. During the follow-up, as many as 59% of patients abandoned the study. CONCLUSION(S): Flutamide is very effective for hirsutism treatment; however, adverse effects are very frequent and associated with low long-term compliance. |
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Authors:
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Camil Castelo-Branco; Dolores Moyano; Olga Gómez; Juan Balasch |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2008-03-12 |
Journal Detail:
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Title: Fertility and sterility Volume: 91 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-05-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1183-8 Citation Subset: IM |
Affiliation:
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Faculty of Medicine-University of Barcelona, Institut Clinic of Gynecology, Obstetrics and Neonatology, Hospital Clinic-Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain. castelobranco@ub.edu |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Androgen Antagonists / adverse effects, therapeutic use Contraceptives, Oral, Hormonal / administration & dosage, adverse effects Desogestrel / administration & dosage, adverse effects Ethinyl Estradiol / administration & dosage, adverse effects Female Flutamide / administration & dosage, adverse effects*, therapeutic use* Follow-Up Studies Hirsutism / drug therapy* Humans Time Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Androgen Antagonists; 0/Contraceptives, Oral, Hormonal; 13311-84-7/Flutamide; 54024-22-5/Desogestrel; 57-63-6/Ethinyl Estradiol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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